On 6 June 2014, Gallardo was presented as the new manager of River Plate following the controversial resignation of Ramón Díaz on 27 May. Key players from the previous tournament, Carlos Carbonero, Manuel Lanzini, and Cristian Ledesma left the club, while players relegated by Ramón Díaz such as Carlos Sánchez and Rodrigo Mora returned. River Plate only bought two players: an attacking midfielder, Leonardo Pisculichi (who had been relegated to second division with Argentinos Juniors) and goalkeeper Julio Chiarini (from Instituto de Córdoba).
River eliminated Boca with a lone goal from Leonardo Pisculichi in the second leg played at the Monumental. In the 2014 Copa Sudamericana Finals, Pisculichi scored once again to draw 1–1 against Atlético Nacional in the away leg at the Estadio Atanasio Girardot. Defenders Gabriel Mercado and Germán Pezzella, in the span of four minutes, scored with headers in the second leg at the Monumental, giving River Plate a 2–0 win and its first international title since 1997, remaining unbeaten in the competition. Marcelo Gallardo became the first River Plate player to win an international title both as a player and a coach. Following the end of the game, Gallardo dedicated the win to his mother, who had died shortly before the second game against Boca Juniors.