Born in Culiacán, Marco Bueno started his career in the youth system of CF Pachuca. He was loaned to Leon during the Liga Ascenso Clausura 2011 season and made only one appearance as a starter but was subbed off after 58 minutes without having scored. He returned to Pachuca at the end of the season. He made his official debut for CF Pachuca on 8 October 2011 against Chiapas on 83rd minute for Mauro Cejas on the 12th match of the Apertura 2011.

Marco Bueno was selected by manager Raul Gutierrez to compete in the 2011 FIFA U-17 World Cup. He would compete in every match scoring only 1 goal against Panama in the round of 16. He would eventually go on and win the tournament at the Estadio Azteca becoming the first home nation to win it on home soil.

On the Clausura 2012 Bueno played 2 minutes in the 0-0 Draw against Santos Laguna on the 1st match of the tournament on 7 January 2012. Bueno scored his first two goals the following week against Puebla on the 2nd match of the tournament.

Marco Bueno was loaned out to Estudiantes Tecos from CF Pachuca on 1 January 2014. He went on to help Estudiantes Tecos win the playoffs and enter a chance to get promoted to top division, Liga MX, but lost the promotion game against Leones Negros on penalties.

On 15 April 2015, he made his debut with the Mexico national team in a friendly game against the United States.

It was confirmed on 26 May 2016 that Marco Bueno had joined all Mexican team Chivas de Guadalajara on a year loan with the option of making it permanent.

After his loan in Chile at Everton and not finding a spot in Pachuca for the Clausura 2019, Marco Bueno joined HJK on trial on 21 March 2019 as a free agent, Marco played two days later and scored on his debut in a friendly match. On March 26, 2019 he signed a 1+1 contract.