She released her first song in 1957, “Nitsa, Elenitsa (Little Helen)”. Her early career was marked by her collaboration with singer Stelios Kazantzidis. Together they managed to become the greatest duet of Greece, unsurpassed even today. Starting at the night club “Luxembourg” in Thessaloniki where they enjoyed great success, they later moved to Athens, the capital, where they became widely known. They sang the songs of Mikis Theodorakis, Manos Hadjidakis, Vassilis Tsitsanis, Giorgos Mitsakis, Giorgos Zambetas, Apostolos Kaldaras, Theodoros Derveniotis, Stavros Xarchakos, Christos Leontis, whom are considered the best composers of the era.

Marinella married Stelios Kazantzidis on 7 May 1964 and they toured together in Germany and the United States. They divorced in September 1966. Marinella then began a solo career and eventually in 1974 married singer Tolis Voskopoulos. This second marriage also ended in divorce in 1981.

In October 1970, Marinella participated in the V Festival Internacional da Cançao Popular – Parte Internacion (FIC) in Rio de Janeiro, representing Greece with the song “Kyra Giorgena (Wife of George)”, finishing 4th among 38 countries. On October 24, 1970, the Billboard wrote “Marinella from Greece, knows audiences in Athens clubs, carries enchantment in her songs and the warmth of the sun in her voice” (by Henry Johnston).

On 27 April 1998, Marinella performed in the Athens Concert Hall, performing her older hits to great acclaim. Her concert at the small Olympic Stadium of Athens on 1 October 1999 was a great success with more than 25,000 people.

In November 2002, she collaborated with George Dalaras. They performed concerts in Athens and Thessaloniki as well as abroad. The tour was titled “Mazi (Together)” and the released live album from these performances reached platinum status in 2003.

On 10 April 2003, The New York Times critic wrote about Marinella, “Her voice was earthy and strong, and she had the presence of an actress as she danced a few teasing steps or brought dignity to longing” (by Jon Pareles).

In March 2004, she released a brand new album with new songs by Nikos Antypas and Lina Nikolakopoulou, entitled “Ammos Itane (It was sand)”. In the same year, on 19 August, she performed at the closing ceremony of the 2004 Summer Olympics, along with Dimitra Galani, Haris Alexiou, Yiannis Parios and George Dalaras. In December 2005, she released a new album titled “Tipota Den Ginete Tihea (Nothing is random)”, composed by Giorgos Theofanous. The album reached gold status and includes duets with famous Greek singers, such as Antonis Remos and Glykeria. In 2006, two new compilations of Marinella were officially released, the first titled “Sti Skini (On stage)” and containing older live recordings and the second one titled “Ta Logia Ine Peritta – 50 Chronia Tragoudi (Words are pointless – 50 Years of song)”, which is a complete eight CDs boxset with Marinella’s greatest hits from the beginning of her career until her collaboration with Kostas Hatzis at “Recital”. She returned to nightlife, by performing live with Antonis Remos at the Athens Arena in 2006–07 and 2007–08, with Giannis Parios at the Diogenis Studio in the winter season 2008–09, and with Natassa Theodoridou at the Votanikos in 2011–12, in Athens.