Ramírez was born on 4 July 1954 in Zipaquira, Colombia to Álvaro Ramírez Suárez and Alba Blanco Venturoli, the eldest and only daughter of their four children. In 1974 she married Álvaro Rincón, a Colombian architect; together they have one daughter, María Alejandra. She is of Italian descent through her mother, and thorough her father, she is related to Jesús Ramírez Suárez, her uncle, who served as Chamber Representative for Cundinamarca.

A lawyer from the Pontifical Xavierian University, she holds a specialization degree in Legal Sciences and Socioeconomics, and postgraduate specialisations in Financial Law from the University of the Andes, and in Business Management from La Sabana’s INALDE Business School. In 1996 she received a fellowship from Harvard University’s Center for International Affairs, focusing on the internationalisation of the Colombian economy in the context of the rise of regional blocks and economic and commercial integration.

In 1997 Ramirez returned to Colombia as Noemi Sanin’s campaign manager who ran for office in 1998. When Sanin lost the race, the new president Andres Pastrana appointed Ramirez as Minister of Foreign Trade from 1998 until 2002. During this period she was rated as the best minister of Pastrana’s cabinet in several polls. Her most important achievements were the design and implementation of a 10-year Strategic Plan for exports, competitiveness and entrepreneurship policy for Colombia. At the end of Pastrana’s administration, Ramirez was appointed as Colombian ambassador to France. Only four months later, Alvaro Uribe was elected President and appointed Ramirez to become his Defence Minister.

In 2002 Ramírez was then appointed as ambassador of Colombia in France for a few months. With the election of Álvaro Uribe as President of Colombia, Ramírez went back to Colombia.

Marta Lucia Ramirez was the 20th Minister of National Defence the second woman in Latin America to hold this title after Michelle Bachelet who later became President of Chile. Ramirez served as Defence Minister from 2002 until 2003. Her most significant contributions to Alvaro Uribe’s government were the design and implementation of a 10-year Democratic Security Policy and her focus on civilian control over the military in order to maintain efficiency and legitimacy of the military forces in the war against the Colombian guerrillas, paramilitaries and narcotrafickers. During her term in the Defence Ministry, she designed and implemented the massive demobilisation program for guerrilla members, which focuses on young guerrillas to combat the FARC’s recruitment of child soldiers. Under the leadership of President Uribe, she also implemented the security of Colombian roads through a program called “Live Colombia travel through it”, and designed a program focused on transparency and efficiency in the military procurement. She also initiates a group of civilian advisors to implement a reform in the Colombian Police, in order to complement the military fight against terrorism in urban locations. After serving as the Ministry of Defence, Ramirez became a private consultant in trade and security. She then became advisor for the World Trade Organisation where she was appointed Chairwoman for the panel of experts at the Airbus-Boeing Trade panel. She resigned to run for the Colombian Senate in 2006 where she was elected with a high majority of opinion votes in the U Party, a new political party organised under Uribe’s government.

Elected as President of the International Affairs and Defence Commission in the Colombian Senate. As a senator she authored Law 1253/08 law for Colombian competitiveness; 1286/09 law for Science Technology and Innovation; 1190/09 law in favor of displaced people and different bills for public Universities, women protection, bilingual education and also presented political control debates to the executive branch. Due to her critics because of clientelism and corruption within the party, she organized dissidence with Gina Parody and Nicolas Uribe. Later Ramirez was against a third election of Alvaro Uribe as a Colombian president so she decided to resign from the party and the Congress. In 2010 she participated as a candidate for the Colombian presidency within the conservative party to which she still belongs.

On 17 June 2018, Ramírez was elected Colombia’s first female Vice President, alongside former Senator Iván Duque Márquez.