In 1998, Sargent joined the ZDTV (later TechTV) TV show Call For Help as the show’s “Resident Craft Professional” and substitute co-host. In 2001, he moved from Call For Help to another TechTV show, The Screen Savers, and became known first as “The Twisted Lister”, for producing and presenting odd, “twisted” top-five lists on the show, and later for another segment, “Site of the Night”, in which he presented strange websites.

Sargent left The Screen Savers in April 2003, to host his own show, Unscrewed with Martin Sargent, anchoring a newly introduced late-night programming block.

On March 25, 2004, Comcast’s G4 gaming channel announced a merger with TechTV. This move became hugely controversial among loyal fans of TechTV. Around May 6, G4 announced the termination of 250 employees from the San Francisco office by July 10, 2004, allowing approximately 80 to 100 employees to transition to G4’s main office in Los Angeles, California if they agreed to relocate there. Sargent chose to stay with G4 and moved to Los Angeles.

Six months later, on November 11, 2004, G4TechTV canceled Unscrewed and terminated Sargent, along with many other former co-workers from TechTV.

Exactly one year after his termination, Sargent launched Infected, a comedy podcast distributed by the internet production company Revision3. Infected was hosted by Sargent and “The Gator” (portrayed by co-writer Jay Speiden, who died in December 2016), produced by Joey Rabier, and was structured as a conversation between co-hosts and producer, with fake “commercials” for various real and fictional products as well as occasional guest callers. Recurring callers included inventor Alex Chiu as well as the fictional characters Johnny O’Banion (portrayed by co-writer/producer Stewart Engesser), a Hollywood reporter and former Loni Anderson paramour, and karate master Rickey Kang (also played by Spieden). O’Banion and Kang were recurring characters on Infected, and Rabier acted as a production assistant on the show and also appeared as his “intern” character for selected skits. The podcast was originally available in audio-only format, then offered an alternative video version consisting of a montage of still photographs relating to the topic discussed and taken at the recording session. The video version has since been offered in full-motion video. Infected was canceled in December 2007, after 50 episodes.

On January 30, 2008, the Revision3 website released the first episode of Martin Sargent’s new show, Internet Superstar.

In November 2009, Martin and long-time associate Molly McDonald became engaged.

Starting February 12, 2009, he and Sarah Lane appeared together in a Podcast on Leo Laporte’s TWiT.tv network called This Week in Fun. The show aired for just shy of a year before going on hiatus in January 2010, following Martin’s employment at Goodby, Silverstein & Partners in San Francisco. The show was left on good terms with the TWiT network, though they have made no solid plans of returning to production.