Blige's eighth studio album, Growing Pains, was released on December 18, 2007, debuting at number two on the Billboard 200 and at number one on the Top R&B/Hip-Hop Albums chart. It sold 629,000 copies in its first week, marking the third time since Nielsen SoundScan began collecting data in 1991 that two albums sold more than 600,000 copies in a week in the United States. In its second week, the album climbed to number one, making it Blige's fourth number-one album. The lead single, "Just Fine", peaked at number twenty-two on the Billboard Hot 100 and at number three on the Hot R&B/Hip-Hop Songs chart. "Just Fine" was nominated for the Grammy Award for "Best Female R&B Vocal Performance", and Blige won "Best R&B Performance by a Duo or Group with Vocals" for the Chaka Khan duet "Disrespectful" (featured on Khan's album Funk This) which Blige wrote.
Blige was featured on 50 Cent's 2007 album, Curtis, in the song "All of Me". In March 2008, she toured with Jay-Z in the Heart of the City Tour. They released a song called "You're Welcome". In the same period, cable network BET aired a special on Blige entitled The Evolution of Mary J. Blige, which showcased her career. Celebrities such as Method Man and Ashanti gave their opinions about Blige and her music. Blige is featured on singles by Big Boi, and Musiq Soulchild. Growing Pains was nominated for and won the Grammy Award for "Best Contemporary R&B Album", at the 51st Grammy Awards held on February 8, 2009, earning Blige her 27th Grammy nomination, in a mere decade. Blige went on the Growing Pains European Tour, her first tour there in two years. A tour of Australia and New Zealand was scheduled for June but was postponed due to "weariness from an overwhelming tour schedule" and then eventually canceled entirely.
In February 2007, Blige guest-starred on Ghost Whisperer, in an episode called "Mean Ghost", as the character Jackie Boyd, the school's cheerleader coach grieving for the death of her brother and affected by the ghost of a dead cheerleader. The episode features many of Blige's songs. In August 2007, Blige was a guest star on Entourage, in the role of herself, as a client of Ari Gold's agency. In October 2007, Blige was also a guest star on America's Next Top Model, as a creative director for a photoshoot by Matthew Rolston. In May 2009, Mary made a guest appearance on 30 Rock, as an artist recording a benefit song for a kidney. Blige also had a supporting role in Tyler Perry's movie I Can Do Bad All by Myself, which was released in September 2009.