Ouellet was officially signed to a WWE developmental contract on August 24, 2007 and was assigned to OVW for training. She made her in-ring debut at an OVW live event in December 2006. In March 2007, she began wrestling in dark matches prior to the OVW television tapings. In mid-2007, Ouellet began managing Sylvain Grenier. When Florida Championship Wrestling (FCW) opened in mid-2007, Ouellet was transferred to the new developmental facility, and on September 25, she made her FCW debut as the valet of Ryan O’Reilly along with Lacey Von Erich. Ouellet then started competing in singles and tag team competition, before managing Ted DiBiase, Jr. in December 2007, and was at ringside when he captured the FCW Southern Heavyweight Championship.

In April 2007, she appeared alongside fellow WWE Divas Ashley, Torrie Wilson, Brooke Adams, Layla, and Kelly Kelly in Timbaland’s music video “Throw It On Me” featuring The Hives.

By the time she began appearing regularly on SmackDown at the beginning of 2008, she had adopted a snobby attitude and become a villainous character. On the March 7, 2008 episode of SmackDown, Maryse competed in a swimsuit contest against Victoria, Michelle McCool, Cherry, and Eve Torres, which ended in a brawl between Maryse and Torres. The following week, she was the first eliminated from another swimsuit competition. On March 28, Maryse competed in a “Wet and Wild” match, teaming with Victoria against Cherry and McCool in a losing effort. On a “SmackDown after the bell” video on WWE’s website, the tag team Deuce ‘n Domino dumped Cherry, who had been their manager, and replaced her with Maryse. Maryse then insulted Cherry, only for Cherry to slap her. On the May 16 episode of SmackDown, Maryse made her in-ring debut in a loss to Cherry, though she defeated Cherry in a rematch the following week. On the June 6 episode of SmackDown!, SmackDown General Manager Vickie Guerrero announced the creation of the WWE Divas Championship, and that same night the Divas competed in a Golden Dreams match to qualify for the championship match at The Great American Bash, which was won by Natalya. On the July 4, 2008 episode of SmackDown!, she competed again in another Golden Dreams match to face Natalya for the championship, however she failed to win. For several weeks, Maryse competed in six-person tag team matches with Victoria and Natalya against Cherry, Michelle McCool and Maria. She suffered a minor broken nose after receiving a bulldog from Maria in August 2008.

Maryse began a rivalry with Michelle McCool in September 2008, challenging her for the WWE Divas Championship at Unforgiven, and in a rematch the following week on SmackDown, but failed to win on both occasions. On the September 23 episode of ECW, Maryse defeated McCool in a non-title match. After a month-long absence, Maryse returned at Survivor Series pay-per-view event in November, participating in a five-on-five Divas elimination tag team match, eliminating Kelly Kelly, Mickie James and Candice Michelle; Maryse was the sole survivor of her team, but was ultimately eliminated by Beth Phoenix. At the Armageddon pay-per-view on December 14, Maryse teamed up with Jillian Hall, Victoria and Natalya in a losing effort to McCool, Maria, Kelly Kelly and Mickie James in an Eight-Diva Santa’s Little Helper tag team match. On December 19, Maryse pinned Maria to become the number one contender for Michelle McCool’s Divas Championship. The following week on SmackDown, Maryse defeated McCool, with Maria as the special guest referee, to win her first Divas Championship. On December 28, at a house show in Raleigh, North Carolina, Maryse dislocated her knee in a tag team match against The Bella Twins (Nikki and Brie). It was later announced that the injury was not major, and therefore only missed a few weeks action. On the January 23, 2009 episode of SmackDown, Maryse returned and sat at ringside commentating during a Divas’ tag team match. She returned to in-ring action on February 20, teaming with Michelle McCool in a win against Maria and Eve Torres, where she pinned Torres.

In early 2010, a tournament was held for the newly vacated WWE Divas Championship due to Melina’s injury. Maryse entered the tournament, and defeated Brie Bella and Eve Torres in the first round and semi-finals, respectively, to advance to the finals. The tournament’s finals were originally scheduled for Elimination Chamber on February 21; instead, the match was changed by the SmackDown General Manager Vickie Guerrero to an interbrand tag team match, where Maryse teamed with her scheduled opponent Gail Kim against LayCool (Michelle McCool and Layla), which was won by LayCool as a result of Maryse abandoning Kim during the match. The following night on Raw, Maryse defeated Kim in the finals to win the championship, becoming the first Diva to have held it twice.

Ouellet also made an appearance in the January 2009 issue of Muscle & Fitness, along with Eve Torres and Michelle McCool. She and John Morrison were interviewed on Eurosport in the same year. She also made a special appearance on Redemption Song, which was hosted by WWE wrestler Chris Jericho, along with Candice Michelle, Mickie James, and Eve Torres. She has also appeared in several newspaper interviews, including Tokyo Headline, and was on the cover of Sessions Magazine in October 2010.

Following her release from WWE in 2011, Ouellet announced her plans for a clothing and jewelry line named House of Maryse.

On October 5, 2012, Maryse appeared at the Family Wrestling Entertainment (FWE) event Back 2 Brooklyn, performing live commentary. She began appearing regularly for FWE, where she commentated during women’s matches.

In 2012, Maryse was featured on the cover of Le Journal de Montréal, and on MDA Show of Strength with The Miz and other celebrities. In 2015, Ouellet had roles in Sharknado 3: Oh Hell No! and in Santa’s Little Helper, the latter starring The Miz. In the same year, she appeared on the E! reality television series WAGS. In 2016, it was announced that Maryse would appear as a main cast member on the sixth season of Total Divas, which prompted her return to WWE. In June 2017, Maryse along with Miz were cover of the DUB Magazine with a Jeep car.

Beginning in late 2013, Ouellet began working as a realtor in Los Angeles after spending a year earning her real estate license.

In 2013, Ouellet got engaged to longtime boyfriend and fellow wrestler Mike Mizanin, better known by his ring name, The Miz. The two were married in The Bahamas on February 20, 2014. On March 27, 2018 Maryse gave birth to their first child, a daughter named Monroe Sky Mizanin. During Elimination Chamber on February 17, 2019, the couple announced they are expecting their second child, due in September. Their daughter Madison Jade Mizanin was born on September 20, 2019.

As part of the 2009 WWE Draft on April 13, Maryse was drafted to the Raw brand, and in the process, the Divas Championship became exclusive to Raw. She made her first appearance as part of the brand on April 27, teaming with Beth Phoenix, Rosa Mendes, and Jillian Hall in a loss to Santina Marella, Mickie James, Brie Bella and Kelly Kelly. Maryse then began feuding with Mickie James after she cost James a number one contender’s battle royal, which was eventually won by Kelly Kelly, by spraying hairspray in her eyes. The following week, Maryse lost a championship match against Kelly by disqualification, meaning the championship did not change hands, and won a subsequent rematch by pinfall two weeks later on June 8. At Night of Champions on July 26, Maryse lost the Divas Championship to James. Despite being only the second Divas champion, her reign of 216 days remained the longest in the title’s history for nearly five years, until AJ Lee surpassed her reign in January 2014.

On April 4, 2016 episode of Raw, the episode after WrestleMania 32, Maryse returned during a WWE Intercontinental Championship match between the champion Zack Ryder and her husband, The Miz. During the match, Maryse slapped Ryder’s father, who was in the front row, in order to distract Ryder and allowed Miz to capture the championship for the fifth time, thus becoming his manager in the process, where the two then became an on-screen power couple. She formally re-introduced herself three days later on the April 7 episode of SmackDown before once more helping Miz to retain his championship over Ryder. She then began to cut various promos with Miz as his host during the “Miz TV” segments, while calling themselves the “It” Couple. Following a hiatus due to the shoot of a WWE film, Maryse returned to WWE television on the June 27 episode of Raw, where she helped Miz to retain his championship against Kane after she faked an ankle injury.

On February 2017, Maryse was involved in her first feud since her return when she and The Miz feuded with the also real-life couple Nikki Bella and John Cena. This culminated in a mixed tag team match at WrestleMania 33, where Maryse and Miz would lose in what was Maryse’s first match in over six years. On April 10, Maryse was drafted to the Raw brand along with Miz as part of the “Superstar Shake Up”. On June 4, at Extreme Rules, Maryse was in Miz’s corner when he won the WWE Intercontinental Championship for the seventh time by defeating Dean Ambrose. In September, following her pregnancy announcement, Maryse stopped appearing on television. On November 19, 2017, she made an appearance on the Survivor Series pay-per-view crowd watching Miz fight United States Champion Baron Corbin.

On January 22, 2018, in the Raw 25 Years special episode, Maryse was honored as part of a segment involving women considered legends that contributed to the company’s success, including the Bella Twins, Kelly Kelly, Lilian Garcia, Torrie Wilson, Michelle McCool, Terri Runnels, Maria Kanellis and the Hall of Famers Jacqueline and Trish Stratus. Later she started making backstage promotional videos with Miz supporting him in the WWE Mixed Match Challenge, in which he won alongside Asuka in April in support of the charity Rescue Dogs Rock.

Maryse returned to Smackdown to manage The Miz in July 2018. Following Maryse’s interfence in The Miz vs. Daniel Bryan match at Summerslam, Maryse and Miz were put in a mixed tag match by the SmackDown General Manager Paige against Brie Bella and Daniel Bryan at Hell in a Cell on September 16 and won. On the September 11 edition of SmackDown Live, Maryse competed in her first singles match in over 8 years, losing to disqualification to Brie Bella. Following this match, Maryse would again stop appearing on television as Miz began a storyline with Shane McMahon. At Elimination Chamber Maryse returned as a face announcing she and The Miz are having their second child. Although Miz was drafted to SmackDown during the 2019 WWE Draft, Maryse went undrafted. Her first post-draft appearance occurred during a pre-recorded segment on SmackDown in December 2019 for Miz’s feud with “The Fiend” Bray Wyatt, where she appeared with Miz at their home.

In 2018, Maryse and her husband Mike appeared in a reality television series titled Miz & Mrs. It was later announced on July 26 that Maryse would not be returning for the eighth season of Total Divas.

On June 27, 2018, Maryse officially became an American citizen. The couple resides in Thousand Oaks, California as of 2019.