Fraction teamed with Ed Brubaker for a run on Marvel’s The Immortal Iron Fist. The pair re-teamed on Uncanny X-Men for a short time, after which Fraction wrote the series solo until leaving it in 2011. He wrote The Mighty Thor and The Invincible Iron Man, the latter of which led to his consulting work on the set of the film Iron Man 2 and writing the Iron Man 2 video game that tied into that film sequel.

In 2011 Fraction wrote the Fear Itself limited series, which was the central part of the crossover storyline of the same name. In December 2011 he revived the series The Defenders with artist Terry Dodson and in August 2012 he started a new Hawkeye series with David Aja. As part of Marvel NOW!, Fantastic Four was relaunched in November 2012 with the creative team of Fraction and artist Mark Bagley. Its spinoff series FF was produced by Fraction and artist Mike Allred. Fraction left both series due to other work commitments.

In February 2013, he was named on IGN’s list of “The Best Tweeters in Comics”, which described him as “the premier comics Twitter personality.”

In 2013, Fraction and Chip Zdarsky co-created the Sex Criminals series for Image Comics. He and Christian Ward created the ODY-C series in 2014, a science-fiction retelling of the Odyssey with the characters’ genders changed to women.