In 2019, Muncy was selected to the 2019 Major League Baseball All-Star Game as an injury replacement, his first all-star appearance, replacing Washington Nationals third baseman Anthony Rendon. On August 30, 2019, Muncy was placed on injured list with a wrist fracture. He finished the 2019 regular season, playing in 142 games, hitting .251/.374/.515 with 35 home runs (for the second season in a row) and a career-high 98 RBIs. Muncy also received two MVP votes.