By taking part in the first free practice at the 2014 Japanese Grand Prix, Verstappen became the youngest driver to take part in a Grand Prix weekend, as part of his preparation for a full-time place with Scuderia Toro Rosso in 2015.
In January 2015, the FIA launched a new super licence system for Formula One, raising the age limit to 18 from the 2016 season onwards. Verstappen became the youngest driver to start a World Championship race by joining the sport a year before this licence restriction, in his Grand Prix debut as a full-time driver at the 2015 Australian Grand Prix at the age of 17 years, 166 days – breaking Jaime Alguersuari's existing record by almost two years. In this first race, Verstappen ran in points-scoring positions until he was forced to retire due to an engine failure. However, at the subsequent race in Malaysia, Verstappen qualified sixth and finished the race in seventh place, scoring his first Formula One points aged 17 years, 180 days, breaking the record of youngest driver to score World Championship points. After that he then failed to finish with points in China, due to engine failure in the last lap, Bahrain, due to electrical issues, Spain, settling for 11th.
At the 2015 Monaco Grand Prix, Verstappen was involved in a high-speed collision with Romain Grosjean, after clipping the back of the Lotus on the approach to Sainte Devote and flew nose-first into the barriers at high speed. Verstappen was given a five-place grid penalty for causing the accident, and was branded "dangerous" by Williams driver Felipe Massa – although Verstappen hit back at Massa by pointing out he had himself been involved in a similar incident with Sergio Pérez at the 2014 Canadian Grand Prix.
Verstappen holds numerous "firsts" in Formula One racing. In 2015, he became the youngest driver to compete in Formula 1 at the 2015 Australian Grand Prix for Scuderia Toro Rosso. He is also the youngest driver to lead a lap during a Formula One Grand Prix, youngest driver to set the fastest lap during a Formula One Grand Prix, youngest driver to score points, youngest driver to secure a podium, youngest Formula One Grand Prix winner in history, youngest multiple Grand Prix winner, youngest to win the same Grand Prix multiple times and youngest to win the same Grand Prix in successive years. On 3 August 2019, he became the first ever Dutch F1 driver to take pole position, for the Hungarian Grand Prix, while also setting a new lap record on the Hungaroring and becoming the 100th polesitter in the sport's history.