She wrote and directed her first feature film, First Aid For Choking, in 2003. Griffiths subsequently worked as a producer and first assistant director on features in and around Seattle including Zoo, The Immaculate Conception of Little Dizzle, The Catechism Cataclysm, and Your Sister's Sister. Her second feature The Off Hours world premiered at the 2011 Sundance Film Festival and went on to receive a nomination at the 2011 Independent Spirit Awards for Ben Kasulke's cinematography.