MacRae married Richard Berger, former president of MGM, in 1964, but they divorced four years later. In 1969, she married fellow actor Greg Mullavey (famous for Mary Hartman, Mary Hartman) and had one child with him, Alison, before divorcing in 1987. Her third and final marriage was in 1995 to Phillip M. Neal, chairman and CEO of Avery-Dennison at the time of their marriage.

In 1966, MacRae signed a contract with CBS to play Billie Jo Bradley on the sitcom Petticoat Junction, starring Bea Benaderet as her television mother and Edgar Buchanan as her television uncle. Her television sisters were Betty Jo, played by Linda Kaye Henning, and Bobbie Jo, played by Lori Saunders.

MacRae was the sitcom’s third actress to portray Billie Jo. Jeannine Riley played the part in the show’s first two years (1963–1965) and Gunilla Hutton in the third year (1965–1966). Both of these actresses played the role as a typical boy-crazy dumb blonde. However, by MacRae’s debut on the series, Billie Jo’s persona was that of a strong, independent woman who focused more on a singing career, a dream she later accomplishes. She remained with the sitcom until its cancellation in 1970.

MacRae was also popular in the game-show genre, appearing in numerous shows, including: Funny You Should Ask, Match Game (’60s, ’70s, and ’90s versions), What’s My Line?, I’ve Got a Secret, Personality, Snap Judgement, He Said, She Said (with then-husband Greg Mullavey), Tattletales (also with Mullavey), Hollywood Squares, The Dating Game, To Tell the Truth, Password (ABC version), $10,000 Pyramid, $25,000 Pyramid, Break the Bank, Celebrity Whew!, Beat the Clock, Card Sharks, The Cross-Wits, and Family Feud. She had even hosted an unsold game show pilot called $50,000 a Minute alongside Geoff Edwards in 1985.

In the 1980s, she hosted the talk show Mid-Morning Los Angeles, which ran for eight years. She was awarded a local Emmy Award in 1986 for her interviewing skills. Later, she created and hosted Born Famous, a PBS series on which she interviewed the offspring of celebrities.

In 1994, she narrated the audio-book version of columnist Deboarah Laake’s book Secret Ceremonies: A Mormon Woman’s Intimate Diary of Marriage and Beyond.

In January 1999, MacRae began to experience vertigo and a loss of short-term memory. She was evaluated and her symptoms were initially thought to be due to perimenopause. She returned to her doctor complaining of severe headaches. She was told the headaches were most likely due to muscle spasms, and was encouraged to do cervical spine stretching. She obtained a second opinion and was diagnosed with brain cancer, which had already progressed to stage four. Emergency surgery was performed to remove the brain tumor and decrease the pressure in her head. During the operation, she suffered cardiac arrest, but was resuscitated. Though her cancer was terminal, she agreed to be part of an experimental cancer drug program. She experienced an allergic reaction to the medication that caused swelling to her brain. Two more surgeries were required to relieve the pressure. Her imbalance resulted in a fall that caused her to suffer a fracture to her hip.

On July 14, 2000, MacRae died at her Manhattan Beach home at age 56 from complications of brain cancer. Per her wishes, her body was cremated and her ashes scattered in the Pacific Ocean off the coast of California.