In the 2009–10 season, Özil became the key playmaker of Werder Bremen, stepping into the shoes of Brazilian Diego who had left for Juventus, was named the best player of the first leg of the 2009 Bundesliga season. On 1 May 2010, the 33rd match day, Özil played his 100th Bundesliga game, scoring the 1–0 lead in a 2–0 win against his former club Schalke. Özil went on and led Werder Bremen to become third in the league and again to the DFB-Pokal final, however this time it was lost against Bayern Munich by 0–4. In his second season, Bremen finished a respectable third, with Özil contributing 9 goals and 17 assists in 31 league fixture appearances. During the 2009–10 season, Özil was also declared as the "best player of the first half of the season".
Due to his performances in the 2010 FIFA World Cup, Özil ensured his place among Europe's top young talents. He was sought by teams like Barcelona, Arsenal and Real Madrid. English striker Wayne Rooney was one of the many admirers Özil had garnered with his performances in the World Cup, and had even asked Manchester United manager Sir Alex Ferguson to sign the German playmaker. There were reports claiming that a deal was struck for a transfer to Barcelona, but Werder Bremen denied the reports and on 17 August 2010, the team announced that they had reached an agreement with Real Madrid for Özil's transfer. The transfer fee is believed to have been in the region of €15 million. Upon signing, Özil said, "When the offer came in to join Real Madrid, there is no decision to make. Let's be honest – you don't refuse this club. I was in no rush to leave Werder Bremen, but this is one club you say yes to. They are an institution, a club with a fantastic history, stadium and squad full of world-class players. The prospect of performing at the Bernabéu is so awesome you jump straight in."
He walked off the pitch as a second-half substitute to standing ovations in his first two games as a starter at the Santiago Bernabéu Stadium. His first goal came in a league match against Deportivo de La Coruña on 3 October 2010, in a 6–1 victory. Özil's first Champions League goal with Real came in the 14th minute against Milan on 19 October 2010. On 22 December, he made his debut in the Copa del Rey, scoring once in an 8–0 victory over Levante.
On 27 June 2010, Özil played in Germany's win over England in the last 16 match, setting up the fourth goal with a cross to Thomas Müller as Germany triumphed 4–1. During the quarter-final match against Argentina, he assisted the second goal for Miroslav Klose with a cross to ensure the 4–0 final score for the Germans. FIFA announced that he was among the ten tournament players nominated for the Golden Ball.
In 2010, Özil was awarded the Bambi for being a prime example of successful integration within German society.