The final film that Curtiz directed was The Comancheros, released six months before his death from cancer on April 10, 1962. Curtiz was ill during the shoot, but star John Wayne took over directing on the days Curtiz was too ill to work. Wayne did not want to take a co-director credit.
Curtiz died from cancer on April 11, 1962, aged 75. At the time of his death, he was living alone in a small apartment in Sherman Oaks, California. He is interred in the Forest Lawn Memorial Park Cemetery in Glendale, California.