In 2009, he appeared in five episodes of the television series Rescue Me which earned him an Emmy for Outstanding Guest Actor in a Drama Series. Since 2000 Fox has released three books, Lucky Man: A Memoir (2002), Always Looking Up: The Adventures of an Incurable Optimist (2009), and A Funny Thing Happened on the Way to the Future: Twists and Turns and Lessons Learned (2010). Starting in 2010, Fox played a recurring role in the US drama The Good Wife as crafty attorney Louis Canning and earned Emmy nominations for three consecutive years. In 2011, Fox was featured as himself in the eighth season of the Larry David vehicle, Curb Your Enthusiasm. David's character (also himself) becomes a temporary resident of the New York City apartment building that Fox resides in and a conflict arises between the two, whereby David believes that Fox is using his condition (Parkinson's disease) as a manipulative tool. Fox returned in 2017 for a brief appearance, referencing his prior time on the show. On August 20, 2012, NBC announced The Michael J. Fox Show, loosely based on his life. It was granted a 22-episode commitment from the network and premiered on NBC on September 26, 2013.
The New York Times called it "one of the most powerful and talked about political advertisements in years" and polls indicated that the commercial had a measurable impact on the way voters voted, in an election that McCaskill won. His second book, Always Looking Up: The Adventures of an Incurable Optimist, describes his life between 1999 and 2009, with much of the book centered on how Fox got into campaigning for stem-cell research. On March 31, 2009, Fox appeared on The Oprah Winfrey Show with Mehmet Oz to discuss his condition as well as his book, his family and his primetime special, which aired May 7, 2009, (Michael J. Fox: Adventures of an Incurable Optimist).