On July 30, 2009, Oher signed a five-year, $13.8 million contract with the Baltimore Ravens. He started the 2009 season as right tackle, but was moved to left tackle after an injury to lineman Jared Gaither. In week eight, he returned to right tackle.
Oher started every game in 2009, eleven at right tackle and five at left tackle. He played right tackle in his first post-season game, January 10, 2010, against the New England Patriots, and did not allow a single sack as the Ravens won 33–14.
Oher is one of the subjects of Michael Lewis's 2006 book, The Blind Side: Evolution of a Game. Before the book was published, excerpts appeared in The New York Times Magazine as "The Ballad of Big Mike". His portion of the book was adapted for film and was directed by John Lee Hancock. The Blind Side was released in the United States on November 20, 2009. The movie stars Quinton Aaron as Michael Oher, alongside Sandra Bullock and Tim McGraw. The movie was nominated for Academy Awards for both Best Picture and Best Actress for Bullock. Bullock won an Oscar for her portrayal of Leigh Anne Tuohy.