On 20 December 2019, Arteta was appointed head coach at former club Arsenal, signing a deal until 2023. Upon his appointment, he stated that he believed the club had lost direction and that he didn't want players to shirk responsibility: "I want people to take responsibility for their jobs and I want people who deliver passion and energy in the football club. Anyone who doesn’t buy into this, or that has a negative effect or whatever, is not good enough for this environment or this culture.”
On 26 December 2019, Arteta walked out of the dugout for the first time as an Arsenal manager for their Premier League match against Bournemouth which ended in a 1–1 draw, thanks to a second half equaliser from Pierre-Emerick Aubameyang. Despite the draw, he stated he was pleased with the "attitude, passion and the fighting spirit" of his players. On 1 January 2020, Arteta won his first match as an Arsenal manager after a 2–0 win over Manchester United at the Emirates.