In 2012, Kunis co-starred with Mark Wahlberg in Ted, her most commercially successful film to date. The film was directed and co-written by Family Guy creator Seth MacFarlane. Kunis played the girlfriend of Wahlberg's character. When MacFarlane first conceived the project, he considered Kunis too young for the role. However, the film remained in development for several years and when it was finally ready to begin production, he ended up casting her. Ted has received generally positive reviews from critics and was a commercial success, grossing $549 million worldwide. Drew McWeeny of HitFix wrote that Kunis "brings some lovely subtle grace notes to a role that easily could have just been 'the pushy girlfriend'".
GQ magazine named Kunis the Knockout of the Year for 2011, with Men's Health naming her one of the "100 Hottest Women of All-Time". FHM magazine ranked her number 9 on its 2012 Hot 100 list, but she reached number 1 on their 2013 "100 Sexiest Women in the World" list, which brought to an end a four-year run by British women.
Christian Dior signed Kunis in 2012 to be the face of its Spring fashion campaign. In February 2013, she was named Gemfields global brand ambassador and the face of their advertising campaign. Gemfields is a luxury company that produces emeralds, rubies, and amethysts. She visited Gemfields' mine in Zambia. Kunis appeared wearing Gemfields's Rubies for the world premiere of Jupiter Ascending.
Kunis is a supporter of the Democratic Party and Barack Obama. In a 2012 interview, she criticized the Republican Party, saying: "The way that Republicans attack women is so offensive to me. And the way they talk about religion is offensive. I may not be a practicing Jew, but why we gotta talk about Jesus all the time?"
Kunis began dating her former That '70s Show co-star Ashton Kutcher in April 2012. They became engaged in February 2014, and married during the first weekend of July 2015 in Oak Glen, California. The couple have two children: a daughter born in October 2014 and a son born in November 2016.