Domazos was born on 22 January 1942 in Ambelokipi, Athens, just a few blocks away from the Apostolos Nikolaidis Stadium and began his playing career at the age of thirteen with a neighborhood team, Amyna Ampelokipon, whose field was across the street from the Apostolos Nikolaidis Stadium. Panathinaikos scouted his talent and offered him a professional contract. Domazos did not pass up the chance to play for his favourite team and in 1959 (when the first Greek National Championship took place) Panathinaikos signed him at the age of 17. He went on to become a living legend for Greek football and Panathinaikos. He played for Panathinaikos at 1971 European Cup Final. In 1978, after 19 years in Panathinaikos and due to an argument with his coach, he was transferred to AEK Athens. He returned to Panathinaikos in 1980 when the new team president, Yiorgos Vardinogiannis, asked him to end his illustrious career in the team that loved him so much.

His first match with the national team was on 2 December 1959 against Denmark in Apostolos Nikolaidis Stadium (Greece lost 1–3) and his last was on 11 November 1980 against Australia in the same field (3–3). He was the National team captain during these years. In total he was capped 50 times and scored 4 goals.