Park made her entertainment debut in a SK Telecom commercial in 2005. She launched her acting career a year later in the hit sitcom High Kick! (2006). She continued to appear in television dramas, in roles such as the only daughter of a notorious gangster in I Am Sam (2007), and a gumiho (nine-tailed fox in Korean mythology) in an episode of horror-themed drama Hometown of Legends (2008), She played a villainous princess in the period drama Ja Myung Go (2009), and a girl caught between two marathon runners in Running, Gu (2010).

Park’s breakthrough came with the 2010 drama Sungkyunkwan Scandal, a coming-of-age drama in which her character, an intelligent and resourceful young woman, disguises herself as a boy in order to enter the most prestigious learning institution in Joseon. This was followed in 2011 by another success with City Hunter, based on the titular Japanese manga. Park starred opposite Lee Min-ho in a story about a vigilante out for revenge and justice, and the secret service agent he falls for. Park’s success on the small screen resulted in increased advertising offers for the actress.

Park starred in another manga screen adaptation in 2012; in Dr. Jin, a neurosurgeon (played by Song Seung-heon) travels back in time to 1860. Park played dual roles as the protagonist’s girlfriend in the present-day (a comatose doctor), and her doppelgänger in the Joseon era (a sheltered noblewoman).

In February 2013, Park graduated from Dongguk University in Seoul with a degree in Theatre.

In May 2013, Park Min Young ended her contract with the previous management company King Kong Entertainment and has been a free agent for six months. In November 2013, Park signed with new management agency Culture Depot.

Park next starred as a lawyer in the Korean drama Remember on SBS from late 2015 to early 2016, and played a Queen in the historical drama, Queen for Seven Days, which aired in 2017. In September 2017, It was confirmed that Park will be a fixed cast member in Netflix’s variety show Busted!. In November 2017, it was reported that Park Min Young’s contract with her agency Culture Depot has expired. In December 2017, Park signed with new management agency Namoo Actors.

In 2018, Park was cast in her first romantic comedy drama What’s Wrong with Secretary Kim alongside Park Seo-joon. The series was a ratings success, leading to increased popularity for Park. In October, Park held her first fan meeting since her debut 12 years ago titled My Day.

In 2019, Park starred in her second romantic comedy drama Her Private Life alongside Kim Jae-wook. Park played Seong Deok-mi who works as a curator at an art museum but spends her time outside of work as a passionate fangirl of idol groups.

In 2020, she starred in the JTBC romance drama When the Weather Is Fine alongside Seo Kang-joon.