In March 2015, it was announced that Enos had been cast as the lead character in the ABC legal drama series, The Catch, produced by Shonda Rhimes. She plays the lead character Alice Vaughan, the head of a very high-end private detective agency in this "humorous" thriller, which aired its first 10-episode season in spring 2016, and a second season of 10 episodes in 2017 as part of ABC's "TGIT" Thursday-night lineup.
Also in March 2015, it was announced Enos would star alongside Olivia Cooke in Katie Says Goodbye, an independent film. That same year, she starred in Behold My Heart, directed by Joshua Leonard. In 2019, she appears as Marissa Wiegler, a role originated by Cate Blanchett in action drama web television series Hanna, based on the 2011 film of the same name, on Prime Video.