Throughout his international career, Moin had to compete with another wicket-keeper, Rashid Latif. Moin kept wickets in the 1992 Cricket World Cup which Pakistan won and the 1999 Cricket World Cup where Pakistan finished runners up. Latif kept wickets in the 1996 Cricket World Cup and the 2003 Cricket World Cup.

During the 1992 Cricket World Cup Semi-final against New Zealand, Pakistan needed 9 runs for 8 balls before Khan hit a six to make it 3 runs off 7 balls and then hit a boundary to help Pakistan set up a clash in the world cup final with England. In the world cup final, Pakistan were 249 from 50 overs with Khan not getting a chance to bat. However, he took three catches in the match including one of Ian Botham, who went for a duck against an inswinger bowled by Wasim Akram.

In 2005, Moin scored the first century in Pakistan domestic Twenty20 cricket when he smashed 112 off 59 balls for Karachi Dolphins against Lahore Lions in the ABN-AMRO Twenty-20 Cup. At the end of the season, he retired from cricket finishing with 200 not out against Hyderabad, his highest first-class score.

In 2007, Moin signed with the unofficial Indian Cricket League and coached the Hyderabad Heroes. In the 2008 edition of the competition, he coached the expansion team, the Lahore Badshahs.

Moin was appointed the manager of the team in August 2013. He was appointed as the new head coach of the national team on 11 February 2014, replacing Dav Whatmore.

He was appointed chief selector for the Pakistani team in 2013. But in 2015, during the Cricket World Cup 2015 he was removed from the position after the teams poor performance during the World Cup.