In the latter half of 2010, the media reported that Mylène Farmer would work with Line Renaud and Ben Harper in their respective new releases. After thirty years of absence, Line Renaud released her new album in November 2010, which contains "C'est pas l'heure," a duet with Farmer, written by Farmer and Boutonnat. Also in November, Australian band INXS released the album Original Sin as a tribute to the late Michael Hutchence. Farmer covered "Never Tear Us Apart" with Ben Harper, featuring new lyrics in French written by Farmer.
It was announced surprisingly on 27 September 2010 that Farmer would be releasing a new single "Oui mais... non" to lead her next album. Unlike all the previous musical works by Farmer, Boutonnat was not included in the production or composition. Instead Farmer hired RedOne, known for his work with Lady Gaga to produce and write the music for the single. "Oui mais... non" was released to digital downloading markets on 11 October and hit No. 1 on the French download chart. Considering the decline in music sales, it's her most successful single since 2002. This also makes her the only French singer to have number-one hits in four consecutive decades. The following singles, "Bleu Noir" and "Lonely Lisa", hit the top of the charts too, expanding her record with twelve No. 1 singles.
The album Bleu Noir was released on 6 December 2010, produced by Farmer, RedOne, Moby and Archive. It entered the French album chart at No. 1 and remained at the top for three consecutive weeks. It was the 9th best selling album in France in 2010, with more than 300,000 copies sold in only three weeks. It has sold so far 600,000 copies reaching Diamond status within three months of its release. It also broke the record for best debut in the Downloads Chart, with 9,000 copies sold.