Khan made her television debut in 1993 in the show Daak Time (Mail Time) with Uncle Sargam on PTV. She returned as an anchor on ARY Digital’s morning show Breakfast with Nadia. The show went on air from Dubai in 2003. On 13 November 2006, Khan moved to Geo TV to a new live chat and interview show called the Nadia Khan Show (Geo Mazay Say). She interviewed a variety of Pakistani celebrities, artists, performers, religious leaders, athletes and politicians. There were also segments on Islam, health and beauty, and other topics. The show was banned in 2010 by the Dubai government on behalf of court orders. Sources say that Khan showed Pakistani filmstar Noor Bukhari and her husband fight before Bukhari’s interview. Her husband claimed in court that “It was our family matter”. Therefore, the court gave out an order to ban Khan’s show in Dubai for six months.

Khan made her acting debut in 1996 on the show titled Pal Do Pal which was written by Haseena Moin. She received recognition for Bandhan (1997), for which she won PTV Best Actress Award In the same year, a drama serial was released from the private sector, Bharam, written and directed by M. Izhar Bobby, in which Khan played a leading role with young Yasir Nawaz. She later started anchoring morning shows.

In 2005, Khan made a comeback to acting and appeared in the ARY Digital soap serial called Koi To Ho, directed by Haseeb Hassan and written by Danish Javed.

In 2007, Khan was dubbed the “Oprah Winfrey” of Pakistan by Jang Group of Newspapers.

In 2011, Lollywood director and producer Shoaib Mansoor, offered Khan a role in his film Bol.

Khan won the Masala Lifestyle Awards For Best TV Presenter 2008 and Masala Lifestyle Awards For Best TV Presenter 2009, out of five candidates, from Zee Tv, Sony TV, Star Plus and ARY Digital. Khan resumed her anchoring career after a year in August 2011 with Eid Transmission on Dunya News. On 31 March 2012, the Nadia Khan Show returned to Geo TV as a night-time talk show. Her shows are now consumer oriented. She resumed anchoring with a brief year-long run from 2015 to 2016 of her morning show (Nadia Khan Show) on Geo TV. She hosts Croron Mein Khel, a game show, on BOL Entertainment.

On 19 January 2018 she became the First Pakistani beauty, fashion and lifestyle YouTube influencer to reach 100,000 subscribers on her official YouTube channel, Outstyle. Recently in 2019 she started morning show again on ptv home named Morning @ home it is telecasting every monday to friday