In June 1976, he founded Jetro, a cash and carry store in Brooklyn, New York. He acquired Restaurant Depot in 1994, then opened its first New York retail outlet in 1995, and Jetro and Restaurant Depot began operating as sister businesses under Jetro Holdings. In 2003, Warren Buffett agreed to buy a minority share of Jetro Holdings, however, he and Kirsh could not agree on terms. As of August 2018, Kirsh owned 75 percent of Jetro Holdings, which had about 115 Jetro Cash & Carry and Restaurant Depot stores in the United States. That year, the Independent reported that several of Kirsh's companies were registered in the British Virgin Islands and in Liberia, both of which are listed on the Organisation for Economic Co-operation and Development’s tax haven "grey list". Kirsh Holdings Group, Kirsh's primary holding group, continues to own half of Swazi Plaza Properties.