In 1835, Currier started his own lithographic business as an eponymous sole proprietorship. He initially engaged in standard lithographic business of printing sheet music, letterheads, handbills, etc.
However, he soon took his work in a new direction, creating pictures of current events. In late 1835, he issued a print illustrating a recent fire in New York. Ruins of the Merchant's Exchange N.Y. after the Destructive Conflagration of Decbr 16 & 17, 1835 was published by the New York Sun, just four days after the fire, and was an early example of illustrated news. In 1840, Currier began to move away from job printing and into independent print publishing. In that year, the Sun published his print Awful Conflagration of the Steam Boat 'Lexington' in Long Island Sound on Monday Eveg Jany 13th 1840, by Which Melancholy Occurrence Over 100 Persons Perished, another documentation of a news event, three days after the disaster; the print sold thousands of copies.