The daughter of Mr. and Mrs. Charles Walker, she was born and raised in Chicago, Illinois. In 1910, she married Wilbur Mack, and in 1912 they formed the vaudeville team Mack and Walker. By 1929, she had launched a film acting career, her first film role being in Tanned Legs. She appeared in three films in 1929 and easily transitioned to sound films, appearing in another four films in 1930, possibly making the smooth transition because she was never an established actress in silent films.

In 1931, her film career took off, with appearances in 10 films that year, five of which were uncredited. Her marriage ended not long after her film career was on the rise, and from 1932 to 1933, she appeared in 15 films, only five of which were uncredited. In 1935, her career improved, and from this year to 1938, she had 23 film appearances. Her biggest film appearance during this period was in Young Dr. Kildare with Lionel Barrymore and Lew Ayres. Throughout the 1930s, her career was strong, and despite never being a premier star, she repeatedly had solid acting roles. She finished the decade strongly in 1939 with nine film roles, only three of which were uncredited.

The 1940s mirrored her success of the previous decade in many ways, with appearances in 37 films from 1940 to 1947. Later in her career, and over 60 years of age, she slowed her career for a time, not having another role until 1950 when she appeared in Nancy Goes to Rio with Ann Sothern and Carmen Miranda. She appeared in another two films in 1952, then had her last film acting role in 1954 in the film Sabrina with Humphrey Bogart and Audrey Hepburn.

She appeared in 117 movies, settling in Los Angeles, where she was residing at the time of her death on March 22, 1971, at age 85.