In 2010, Hornby co-founded the Ministry of Stories, a non-profit organisation in East London dedicated to helping children and young adults develop writing skills and to helping teachers inspire their students to write.
Hornby has also had extensive collaboration with American singer/songwriter Ben Folds. Their album Lonely Avenue was released in September 2010. Folds wrote the music, with Hornby contributing lyrics. Prior to the album's release, the single "Picture Window" was released on Ben Folds' website. A bootleg version of a song about Levi Johnston written by Hornby and Folds and performed by Folds, appeared on the internet. Remaining Hornby lyrics provided the title song of the 2012 Ben Folds Five reunion album, The Sound of the Life of the Mind.
In 2010 Nick Hornby co-founded Ministry of Stories, a writing charity based in Hoxton, east London. The charity was inspired by Dave Eggers' 826 Valencia model in San Francisco and aims to offer young people a chance to develop writing and literacy skills and develop a love of writing for pleasure.