After studying architecture and establishing himself over the years as an advertising director, he was nominated six times for the DGA Awards, winning the award in 2005. Along with Shawn Lacy Tessaro, he founded the production company Biscuit Films, which has produced many successful advertising campaigns. In 2004, he was originally set to direct The Ring Two but left the film due to "creative differences". In 2012, he directed advertising campaigns for well-known brands such as Adidas, Nike, eBay, Volkswagen, Land Rover, Toshiba, Stella Artois and many others. In 2008, Murro made his directorial debut with Smart People, a comedy presented at the 2008 Sundance Film Festival. In 2011, he was chosen to direct A Good Day to Die Hard but left production in August 2011, to direct the 300 sequel, 300: Rise of an Empire. John Moore was subsequently drafted in to replace him.
