After graduating from John Muir High School in 1965, Butler worked during the day and attended Pasadena City College (PCC) at night. As a freshman at PCC, she won a college-wide short-story contest, earning her first income ($15) as a writer. She also got the “germ of the idea” for what would become her novel Kindred. An African-American classmate involved in the Black Power Movement loudly criticized previous generations of African Americans for being subservient to whites. As Butler explained in later interviews, the young man’s remarks were a catalyst that led her to respond with a story providing historical context for the subservience, showing that it could be understood as silent but courageous survival. In 1968, Butler graduated from PCC with an associate of arts degree with a focus in history.

During the Open Door Workshop of the Writers Guild of America West, a program designed to mentor minority writers, her writing impressed one of the teachers, noted science-fiction writer Harlan Ellison. He encouraged her to attend the six-week Clarion Science Fiction Writers Workshop in Clarion, Pennsylvania. There, Butler met the writer Samuel R. Delany, who became a longtime friend. She also sold her first stories: “Childfinder” to Ellison, for his anthology The Last Dangerous Visions (still unpublished), and “Crossover” to Robin Scott Wilson, the director of Clarion, who published it in the 1971 Clarion anthology.

Butler’s first work published was “Crossover” in the 1971 Clarion Workshop anthology. She also sold the short story “Childfinder” to Harlan Ellison for the anthology The Last Dangerous Visions. “I thought I was on my way as a writer”, Butler recalled in her short fiction collection Bloodchild and Other Stories. “In fact, I had five more years of rejection slips and horrible little jobs ahead of me before I sold another word.”

Starting in 1974, Butler worked on a series of novels that would later be collected as the Patternist series, which depicts the transformation of humanity into three genetic groups: the dominant Patternists, humans who have been bred with heightened telepathic powers and are bound to the Patternmaster via a psionic chain; their enemies the Clayarks, disease-mutated animal-like superhumans; and the Mutes, ordinary humans bonded to the Patternists.

For the next five years, Butler worked on the series of novels that later become known as the Patternist series: Patternmaster (1976), Mind of My Mind (1977), and Survivor (1978). In 1978, she was finally able to stop working at temporary jobs and live on her writing. She took a break from the Patternist series to research and write Kindred (1979), and then finished the series with Wild Seed (1980) and Clay’s Ark (1984).

The third book of the series, Survivor, was published in 1978. The titular survivor is Alanna, the adopted child of the Missionaries, fundamentalist Christians who have traveled to another planet to escape Patternist control and Clayark infection. Captured by a local tribe called the Tehkohn, Alanna learns their language and adopts their customs, knowledge which she then uses to help the Missionaries avoid bondage and assimilation into a rival tribe that opposes the Tehkohn. Butler would later call Survivor the least favorite of her books, and withdraw it from reprinting.

In 1980, Butler published the fourth book of the Patternist series, Wild Seed, whose narrative became the series’ origin story. Set in Africa and America during the 17th century, Wild Seed traces the struggle between the four-thousand-year-old parapsychological vampire Doro and his “wild” child and bride, the three-hundred-year-old shapeshifter and healer Anyanwu. Doro, who has bred psionic children for centuries, deceives Anyanwu into becoming one of his breeders, but she eventually escapes and uses her gifts to create communities that rival Doro’s. When Doro finally tracks her down, Anyanwu, tired by decades of escaping or fighting Doro, decides to commit suicide, forcing him to admit his need for her.

In 1983, Butler published “Speech Sounds”, a story set in a post-apocalyptic Los Angeles where a pandemic has caused most humans to lose their ability to read, speak, or write. For many, this impairment is accompanied by uncontrollable feelings of jealousy, resentment, and rage. “Speech Sounds” received the 1984 Hugo Award for Best Short Story.

Butler’s rise to prominence began in 1984 when “Speech Sounds” won the Hugo Award for Short Story and, a year later, Bloodchild won the Hugo Award, the Locus Award, and the Science Fiction Chronicle Reader Award for Best Novelette. In the meantime, Butler traveled to the Amazon rainforest and the Andes to do research for what would become the Xenogenesis trilogy: Dawn (1987), Adulthood Rites (1988), and Imago (1989). These stories were republished in 2000 as the collection Lilith’s Brood.

In 1984, Butler released the last book of the Patternmaster series, Clay’s Ark. Set in the Mojave Desert, it focuses on a colony of humans infected by an extraterrestrial microorganism brought to Earth by the one surviving astronaut of the spaceship Clay’s Ark. As the microorganism compels them to spread it, they kidnap ordinary people to infect them and, in the case of women, give birth to the mutant, sphinx-like children who will be the first members of the Clayark race.

During the 1990s, Butler worked on the novels that solidified her fame as a writer: Parable of the Sower (1993) and Parable of the Talents (1998). In 1995, she became the first science-fiction writer to be awarded a John D. and Catherine T. MacArthur Foundation fellowship, an award that came with a prize of $295,000.

Her 1998 follow-up novel, Parable of the Talents, is set sometime after Lauren’s death and is told through the excerpts of Lauren’s journals as framed by the commentary of her estranged daughter, Larkin. It details the invasion of Acorn by right-wing fundamentalist Christians, Lauren’s attempts to survive their religious “re-education”, and the final triumph of Earthseed as a community and a doctrine.

In 1999, after her mother’s death, Butler moved to Lake Forest Park, Washington. The Parable of the Talents had won the Science Fiction Writers of America’s Nebula Award for Best Science Novel, and she had plans for four more Parable novels: Parable of the Trickster, Parable of the Teacher, Parable of Chaos, and Parable of Clay. However, after several failed attempts to begin The Parable of the Trickster, she decided to stop work in the series. In later interviews, Butler explained that the research and writing of the Parable novels had overwhelmed and depressed her, so she had shifted to composing something “lightweight” and “fun” instead. This became her last book, the science-fiction vampire novel Fledgling (2005).

Charlie Rose interviewed Octavia Butler in 2000 soon after she was awarded a MacArthur Fellowship. The highlights are probing questions that arise out of Butler’s personal life narrative and her interest in becoming not only a writer, but a writer of science fiction. Rose asked, “What then is central to what you want to say about race?” Butler’s response was, “Do I want to say something central about race? Aside from, ‘Hey we’re here!’?” This points to an essential claim for Butler that the world of science fiction is a world of possibilities, and although race is an innate element, it is embedded in the narrative, not forced upon it.

During her last years, Butler struggled with writer’s block and depression, partly caused by the side effects of medication for high blood pressure. She continued writing and taught at Clarion’s Science Fiction Writers’ Workshop regularly. In 2005, she was inducted into Chicago State University’s International Black Writers Hall of Fame.

Butler died outside of her home in Lake Forest Park, Washington, on February 24, 2006, aged 58. Contemporary news accounts were inconsistent as to the cause of her death, with some reporting that she suffered a fatal stroke, and other indicating that she died of head injuries after falling and striking her head on her cobbled walkway. Another suggestion, backed by Locus magazine, is that a stroke caused the fall and hence the head injuries.

In 2006, the Carl Brandon Society established the Octavia E. Butler Memorial Scholarship in Butler’s memory, to enable writers of color to attend the annual Clarion West Writers Workshop and Clarion Writers’ Workshop, descendants of the original Clarion Science Fiction Writers’ Workshop in Clarion, Pennsylvania, where Butler got her start. The first scholarships were awarded in 2007.

A complete bibliography of Butler’s work and secondary was compiled in 2008 by Calvin Ritch.

Butler maintained a longstanding relationship with the Huntington Library and bequeathed her papers including manuscripts, correspondence, school papers, notebooks, and photographs to the library in her will. The collection, comprising 9062 pieces in 386 boxes, 1 volume, 2 binders and 18 broadsides, was made available to scholars and researchers in 2010.

Butler’s work has been associated with the genre of Afrofuturism, a term coined by Mark Dery to describe “speculative fiction that treats African-American themes and addresses African-American concerns in the context of 20th-century technoculture”. Some critics, however, have noted that while Butler’s protagonists are of African descent, the communities they create are multi-ethnic and, sometimes, multi-species. As De Witt Douglas Kilgore and Ranu Samantrai explain in their 2010 memorial to Butler, while Butler does offer “an afro-centric sensibility at the core of narratives”, her “insistence on hybridity beyond the point of discomfort” exceeds the tenets of both black cultural nationalism and of “white-dominated” liberal pluralism.

Butler herself has been highly influential in science fiction, particularly for people of color. In 2015, Adrienne Maree Brown and Walidah Imarisha co-edited Octavia’s Brood: Science Fiction Stories from Social Justice Movements, a collection of 20 short stories and essays about social justice inspired by Butler. Toshi Reagon adapted Parable of the Sower into an opera. In 2020, adrienne maree brown and Toshi Reagon began collaborating on a podcast called Octavia’s Parables.

Kindred was adapted as a graphic novel by author Damien Duffy and artist John Jennings. The adaptation was published by Abrams ComicsArts on January 10, 2017. To visually differentiate the time periods in which Butler set the story, Jennings used muted colors for the present and vibrant ones for the past to demonstrate how the remnants and relevance of slavery are still with us. The graphic novel adaption debuted as number one New York Times hardcover graphic book bestseller on January 29, 2017. After the success of Kindred, Duffy and Jennings also adapted Parable of the Sower as a graphic novel. They also plan on releasing an adaptation of Parable of the Talents.

In March 2019, Butler’s alma mater, Pasadena City College, announced the Octavia E. Butler Memorial Scholarship for students enrolled in the Pathways program and committed to transfer to four-year institutions.