Upon the election of Sirleaf as president in 2005, Akerele was appointed as the Minister of Commerce and Industry. Following a 2007 cabinet shakeup, she replaced veteran diplomat George Wallace as Minister of Foreign Affairs. On 3 November 2010, Sirleaf dismissed her entire cabinet, including Akerele. She resigned that same day. Following the appointment of Toga G. McIntosh as Akerele's successor, Sirleaf disclosed that Akerele had resigned in order to receive medical treatment for an undisclosed illness.