His father Karel was co-owner of a successful farm-machine factory and small car plant but Otto chose science for his career. After finishing high school (today’s Wolker Grammar School) in Prostějov, Wichterle began to study at the Chemical and Technological Faculty of the Czech Technical University (now the independent University of Chemistry and Technology, Prague) but he was also interested in medicine. He graduated in 1936 and stayed at the university. In 1939 submitted his second doctorate thesis on chemistry, but the Protectorate regime blocked any further activity at the university. However, Wichterle was able to join the research institute at Baťa’s works in Zlín and continue his scientific work. There he led the technical preparation of plastics, namely polyamide and caprolactam. In 1941, Wichterle’s team invented the procedure to throw and spool polyamide thread thus making the first Czechoslovak synthetic fiber under the name silon (the invention came independently of the original American nylon procedure in 1938). Wichterle was imprisoned by the Gestapo in 1942 but was released after a few months.

After World War II Wichterle returned to the university, specializing in organic chemistry, and was active in teaching general and inorganic chemistry. He wrote an inorganic chemistry textbook, the concept of which was ahead of its time, and also wrote a German and Czech organic chemistry textbook. In 1949 he expanded his second doctorate with the technology of plastics and devoted himself fully to the establishment of a new department of plastics technology. In 1952 he was made the dean of the newly established Institute of Chemical Technology in Prague.

From that time he devoted himself to studying of the synthesis of cross-linking hydrophilous gels, with the aim of finding a material suitable for employment in permanent contact with living tissues. Wichterle accepted the help of one of his colleagues, Drahoslav Lím, and together they succeeded in preparing a cross-linking gel which absorbed up to 40% of water, exhibited suitable mechanical properties and was transparent. This new material was the Poly(2-hydroxyethyl methacrylate) (pHEMA), that they patented in 1953. Wichterle thought pHEMA might be a suitable material for contact lenses and gained his first patent for soft contact lenses. On 1954 this material was first used as an orbital implant. On 1957 Wichterle produced around 100 soft lenses from closed polystyrene molds but the edges split and tore as the lenses were removed. In addition, they required hand finishing. He was determined to find a better way. Unfortunately, Wichterle and other prominent teachers had to leave the Institute of Chemical Technology after a political purge staged by its Communist leadership 1958. Research into contact eye lenses at the Institute of Chemical Technology came to an end. The International Symposium on Macromolecular Chemistry held in Prague in 1957 convinced the state leadership of the need to establish a centre for research into synthetic polymers. The Institute of Macromolecular Chemistry of the Czechoslovak Academy of Sciences (CSAS) came into being in 1958, with Professor Wichterle appointed its director. Since the institute’s building was under construction at that time, Professor Wichterle conducted the decisive experiments to transform hydrogels into a suitable shape of a contact lens at his own home.

Wichterle came to be well-known beyond the frontiers of his country not only through his achievements but also because of his activities in international organizations, chief among which was the International Union of Pure and Applied Chemistry (IUPAC). He took part in the preparations for its Prague symposia in 1957 and 1965, which were much applauded by participants; he had a hand in the inauguration of its fifth, macromolecular, division, of which he was to become the first president, and he gained further credit by combining within it what were for normal administrative purposes the separate fields of pure and applied chemistry.

By late 1961 he succeeded in producing the first four hydrogel contact lenses on a home-made apparatus built using a children’s building kit (Merkur) and a bicycle dynamo belonging to one of his sons, and a bell transformer. All the moulds and glass tubing needed to dose them with monomer were also individually made by himself. On Christmas afternoon, with the help of his wife Linda, using the machine on his kitchen table, he finally succeeded. He tried the lenses in his own eyes and although they were the wrong power they were comfortable. Thus, he invented a new way of manufacturing the lenses using a centrifugal casting procedure. A few days later, he completed his patent application and produced over 100 lenses by spin casting. He built several new prototype machines using Merkur toys with increasing numbers of spindles which required the stronger motor taken from his gramophone. With these rudimental devices, in the first four months of 1962 they made 5,500 lenses. The early experimental lenses were called Geltakt and the later production lenses Spofalens after the state enterprise SPOFA which manufactured them.

In 1965 National Patent Development Corporation (NPDC) bought the American rights to produce the lenses and then sublicensed the rights to Bausch & Lomb which started to manufacture them in the USA. In 1977 the patents were challenged, mainly by Continuous Curve Contact Lenses and in May 1977 the CSAS sold these patents to avoid any liability if the court case failed. However, Wichterle and NPDC won the court case in 1983.

In 1970, Wichterle was expelled again from his position in the institute, this time for signing “The Two Thousand Words” — a manifesto asking for the continuation of the democratization process begun in 1968 during the Prague Spring. Punishment by the regime included removing him from his executive positions and making his research more and more difficult mainly by cutting off contacts from abroad and limiting his teaching opportunities. Full recognition did not come until the Velvet Revolution in 1989. In 1990, he was made president of the Czechoslovak Academy of Sciences till the dissolution of Czechoslovakia and was the honorary president of the Academy of Sciences of the Czech Republic after that. Wichterle was a member of a number of foreign academies of science, he received many awards and honorary doctorates from several universities.

The asteroid number 3899 was named after Wichterle in 1993. Furthermore, a high school in Ostrava (in the district of Poruba) in the Czech Republic was named after him on September 1, 2006.