Mackenzie continued her successful amateur career at the University of Washington in Seattle, where she graduated in 2006 with a bachelor’s degree in business. She recorded 22 top-10 finishes during her collegiate career, placing her first on the Huskies’ all-time list. Among her numerous amateur awards and achievements, Mackenzie was T13 at the 2005 U.S. Women’s Open, was named the 2005 Pacific Northwest Golf Association’s Women’s Player of the Year, and won both the match play and stroke play competitions of the 2005 Trans National Championship. Mackenzie was the 2006 Pac-10 and NCAA West Regional champion and finished her senior year ranked as the No. 1 amateur in the nation by Golfweek.

Mackenzie turned professional in late August 2006 and played two LPGA Tour events on sponsors’ exemptions. She competed on the Cactus Tour in Arizona that fall and qualified for the 2007 Futures Tour, and then won exempt status for the 2007 LPGA Tour season with a T12 finish at the LPGA Final Qualifying Tournament in December 2006.

Mackenzie’s first three of the five LPGA Tour events played in 2006 were as an amateur

She carded three Top-25 finishes in her 2008 campaign, including a 23rd-place finish at the Corona Morelia Championship, a 22nd at the P&G Beauty NW Arkansas Championship and a T24 finish at the Safeway Classic. Mackenzie started 2008 by winning the Sharp Open on the Cactus Tour.

In April 2012, the National Association of Professional Women announced its partnership with Paige Mackenzie who become “NAPW Athletic Spokeswoman”. Paige also starred a nationwide television ad campaign for that professional association during 2012.

^ The Evian Championship was added as a major in 2013.