On July 2, 2019, Corbin chose to wear number 45 in his start against the Miami Marlins to honor the late Tyler Skaggs who died the day before. In 2019 he was 14-7 with a 3.25 ERA (8th in the NL) in 33 starts, in which he struck out 238 batters in 202.0 innings.
In Game 7 of the 2019 World Series, Corbin was the winning pitcher, leading to the Nationals' first championship in franchise history. Corbin’s 13.886 strikeouts per nine innings pitched in the 2019 playoffs was the 3rd highest ever in a single MLB playoffs. Corbin won the 2019 Warren Spahn Award.
Corbin was friends with former teammate Tyler Skaggs, who died on July 1, 2019. They played rookie ball together as well as Class AA baseball. Skaggs was a groomsman in Corbin's 2019 offseason wedding. On July 2, Corbin honored Skaggs by wearing 45 for a game against the Miami Marlins.