When asked in 2011 for the highlight of his career, he chose Star Trek: The Next Generation, because "it changed everything [for me]." He has also said he is very proud of his work on Star Trek: The Next Generation, for its social message and educational impact on young viewers. When questioned about the significance of his role compared to his distinguished Shakespearean career, Stewart has said that: "The fact is all of those years in Royal Shakespeare Company – playing all those kings, emperors, princes and tragic heroes – were nothing but preparation for sitting in the captain's chair of the Enterprise." The accolades Stewart has received include the readers of TV Guide in 1992 choosing him with Cindy Crawford, of whom he had never heard, as television's "most bodacious" man and woman. In an interview with Michael Parkinson, he expressed gratitude for Gene Roddenberry's response to a reporter who said, "Surely they would have cured baldness by the 24th century," to which Roddenberry replied, "In the 24th century, they wouldn't care."
In 2011, Stewart appeared in the feature-length documentary The Captains alongside William Shatner (who played Star Trek Captain James Kirk) – Shatner also wrote and directed the film. In the film, Shatner interviews actors who have portrayed captains within the Star Trek franchise. The film pays a great deal of attention to Shatner's interviews with Stewart at his home in Oxfordshire, as well as at a Star Trek Convention in Las Vegas, Nevada; Stewart reveals the fear and personal failings that came along with his tenure as a Starfleet captain, and also the great triumphs he believes accompanied his role as Picard. In 2016, he narrated Connected Universe, a crowdfunded documentary film directed by Malcolm Carter on the ideas of self-styled physicist Nassim Haramein.
He voiced the narrator of the Electronic Arts computer game, The Sims Medieval, for the game's introduction cinematic and trailer released on 22 March 2011. He also voiced the story plaques and trailer of the MMOG LEGO Universe and the narrator of My Memory Of Us.