By 2019, the city had seen $374 million in private investment for mixed-use developments since Buttigieg had taken office. In 2016, the City of South Bend partnered with the State of Indiana and private developers to break ground on a $165 million renovation of the former Studebaker complex, with the aim to make the complex home to tech companies and residential condos. This development is in the so-called "Renaissance District", which includes nearby Ignition Park. In 2017, it was announced that the long-abandoned Studebaker Building 84 (also known as "Ivy Tower") would have its exterior renovated with $3.5 million in Regional Cities funds from the State of Indiana and $3.5 million from South Bend tax increment financing, with plans for the building and other structures in its complex to serve as a technology hub. While many aspects of South Bend had improved by 2016, a Princeton University study found that the rate of evictions in the city had worsened, more than doubling since Buttigieg took office.
In January 2019, Buttigieg launched the South Bend Home Repair initiative. This expanded the existing South Bend Home Repair Pilot, which helps make available funds to assist residents with home repairs, through the use of $600,000 in city funding (double what the city had earlier pledged to the program) and $300,000 in block grants. It also created two new programs. The first of these is the South Bend Green Corps, which makes funds available to lower-income homeowners for such uses as energy-saving measures and basic weatherization, the installation of smoke and carbon monoxide detectors, lead tests, and energy bill review. It also provides education on reducing energy bills. The South Bend Green Corps was funded with $290,000 from the city and $150,000 from AmeriCorps. The second program is Love Your Block, which assists citizen groups and local nonprofits in revitalizing neighborhoods, and which was funded with $25,000 from the city and $25,000 from the nonprofit Cities of Service.
In September 2019, the city of South Bend finalized a long-anticipated agreement with St. Joseph County to jointly fund the county's $18 million share of the project to double-track the South Shore Line.
In 2019, South Bend launched Commuters Trust, a new transportation benefit program created in collaboration with local employers and transportation providers (including South Bend TRANSPO and Lyft) and made possible by a $1 million three-year grant from Bloomberg Philanthropies Mayors Challenge.
After a white South Bend police officer shot and killed Eric Logan, an African-American man, in June 2019, Buttigieg was drawn from his presidential campaign to focus on the emerging public reaction. Body cameras were not turned on during Logan's death. Soon after Logan's death, Buttigieg presided over a town hall attended by disaffected activists from the African-American community as well as relatives of the deceased man. The local police union accused Buttigieg of making decisions for political gain. In November 2019, Buttigieg secured $180,000 to commission a review of South Bend's police department policies and practices to be conducted by Chicago-based consulting firm 21CP Solutions.
On January 23, 2019, Buttigieg announced that he was forming an exploratory committee to run for President of the United States in the upcoming 2020 election. Buttigieg sought the Democratic Party nomination for president. If he had been elected, he would have been the youngest and first openly gay American president. Buttigieg officially launched his campaign on April 14, 2019, in South Bend.
In July 2019, Buttigieg shared his "Douglass Plan", named after abolitionist Frederick Douglass, to address systemic racism in America. The initiative would allocate $10 billion to African-American entrepreneurship over five years, grant $25 billion to historically black colleges, legalize marijuana, expunge drug convictions, halve the federal prison population, and propose a federal New Voting Rights Act designed to increase voting access.
In 2019, he called for the U.S. to "decriminalize mental illness and addiction through diversion, treatment, and re-entry programs" with a goal of decreasing "the number of people incarcerated due to mental illness or substance use by 75% in the first term."
In July 2019, he released a plan to strengthen union bargaining power, to raise the minimum wage to $15, and to offer national paid family leave.
Buttigieg called for modifying the structure of defense spending, while suggesting that he might favor an overall increase in defense spending. During a speech in June 2019 at Indiana University, Buttigieg called for realigning priorities in military spending "to adequately prepare for our evolving security challenges" rather than for past threats, saying, "In the coming decades, we are more likely than ever to face insurgencies, asymmetric attacks, and high-tech strikes with cyberweapons or drones. Yet our latest defense budget calls for spending more on 3 Virginia-class submarines—$10.2 billion—than on cyberdefenses. It proposes spending more on a single frigate than on artificial intelligence and machine learning."
In June 2019, Buttigieg said: "We will remain open to working with a regime like the Kingdom of Saudi Arabia for the benefit of the American people. But we can no longer sell out our deepest values for the sake of fossil fuel access and lucrative business deals." He supports ending U.S. support for Saudi Arabia in Saudi Arabia's war in Yemen.
In August 2019, Buttigieg released a $300 billion plan to expand mental health care services and fight addiction.
In June 2019, to mark the 50th anniversary of the Stonewall riots, a watershed moment in the LGBTQ rights movement, Queerty named him one of its "Pride50" people identified as "trailblazing individuals who actively ensure society remains moving towards equality, acceptance and dignity for all queer people".