Keoghan co-developed the television show No Opportunity Wasted, initially premiering in 2004, that reflected on this “No Opportunity Wasted” mantra. He also wrote a companion book, No Opportunity Wasted: 8 Ways to Create a List for the Life You Want.

In 2008, Keoghan was awarded the World Class New Zealand award in the ‘Creative’ category.

In June 2010, it was announced that Keoghan would host and produce a new reality series about the Velux 5 Oceans Race. He told TMZ in 2010 that during the 10th season of The Amazing Race he was detained in Ukraine for two days until the U.S. ambassador in Ukraine intervened to free him.

Keoghan originally auditioned for host of Survivor. Though on its shortlist, the CBS network ultimately chose Jeff Probst for Survivor, and offered Keoghan the hosting duties for The Amazing Race. Keoghan has been host for the show from its inception and also serves as a producer. He currently has a contract extending for “several years” following The Amazing Race 18 in 2011 that will allow him to also develop other shows for CBS. In a 2002 interview, he admitted that his pay for a single episode of The Amazing Race is more than an entire year on Spot On.

Keoghan is an avid cyclist. From 28 March to 9 May 2009, Keoghan performed in “Ride Across America”, in partnership with several organisations including GNC, to raise money for multiple sclerosis research. Keoghan and others biked 3,500 miles from Los Angeles to New York City, averaging 100 miles per day. Keoghan stopped in 39 cities en route, attending various events and participating in casting for season 15 of The Amazing Race; the ride culminated a day before the finale of season 14. The event raised $500,000, with over $400,000 coming from in-store donations during the ride. His documentary movie The Ride about his ride across America, premiered on 3 February 2011.

Keoghan was recognised in 2012 as one of six “Emerging Leaders” during the Sir Peter Blake Leadership Awards, due to his use of his celebrity status to support efforts such as Christchurch earthquake relief and efforts for multiple sclerosis.

In the 2014 New Year Honours, Keoghan was appointed a Member of the New Zealand Order of Merit, for services as a television presenter and to tourism.

Keoghan hosted National Geographic Explorer starting in the show’s 11th season, to start airing in 2018. According to Keoghan, he had wanted to produce for Explorer and he and his wife-to-be had even filmed and submitted a pitch tape to the show’s production at that time.