Aubameyang joined A.C. Milan’s youth academy in January 2007. In August, he was part of the squad that finished fourth in the inaugural Champions Youth Cup held in Malaysia, where he made a name for himself and attracted the attention of scouts internationally. He scored against every opponent Milan played, finishing with seven goals in six matches.

For the 2008–09 season, Aubameyang was loaned out to Dijon in France to gain first team experience. His performances there led him to appear in World Soccer’s Talent Scout section in Summer 2009. He finished with a total of ten goals and two assists in all competitions including two goals in Coupe de la Ligue.

On 24 June 2009, it was announced Ligue 1 club Lille had decided to sign Aubameyang on loan. Relative to his previous season, however, Aubameyang did not perform as well, scoring just two goals in 14 appearances, four as a starter.

Aubameyang was invited to play for Italy U19s after a good season with Dijon, but he debuted for the France under-21 team in February 2009 in a friendly match against Tunisia.

On 25 March 2009, Aubameyang was selected for the Gabon national team and made his debut for the squad. He scored his first goal in a 3–2 victory over Morocco, then scored a goal each in friendly matches against Benin, Togo, Algeria and Senegal.

For the 2010–11 season, Aubameyang was loaned for the season to Monaco. On 21 August 2010, he scored his first goal for Monaco in an away match against Lens, then scored again on 29 August at home to Auxerre, where Monaco won 2–0. In January 2011, after six months with the club, Aubameyang was loaned to Saint-Étienne until the end of the 2010–11 season, finishing the season with four goals and three assists. In July 2011, the loan was extended for the entire 2011–12 season.

On 22 December 2011, Aubameyang signed with Saint-Étienne on a permanent deal. He was quickly added to the starting line up and was given the number 7 jersey. In February 2012, he scored his first hat-trick against Lorient. He became an integral part of the squad, scoring half of the team’s away goals during the season, and went on to be Ligue 1’s top goalscorer with 16 goals.

Aubameyang was a key member of the Gabon national side that reached the quarter-finals of the 2012 Africa Cup of Nations as co-hosts of the competition. He netted three goals in total, finishing the tournament as one of the top scorers. On 5 February 2012, he set up the opening goal for his team and hit the post in the quarter-final against Mali. However, the match ended 1–1 after extra time and Aubameyang had his penalty saved in the shootout to decide the game.

In July 2012, Aubameyang represented Gabon at the 2012 Summer Olympics in London. He scored in the team’s opening game against Switzerland, which was Gabon’s first-ever Olympic goal, and would also prove to be Gabon’s only goal of the tournament. They were eliminated in the group stage.

During the warm-up in a match against Lyon, he wore a £2,500 pair of swarovski crystals encrusted boots. On 20 April 2013, Aubameyang was in the starting line-up for Saint-Étienne in the 2013 Coupe de la Ligue Final. Les Verts won the match 1–0 with a goal from Brandão to give Aubameyang his first major trophy as a professional footballer. He finished the season with 18 goals and seven assists in all competitions.

On 4 July 2013, Aubameyang joined 2012–13 Champions League finalists Borussia Dortmund on a five-year contract. He made his competitive debut for his new club on 27 July 2013 against Bayern Munich in the DFL-Supercup, replacing Jakub Błaszczykowski for the last 18 minutes of Dortmund’s 4–2 victory, assisting Dortmund’s final goal, scored by Marco Reus. On 10 August, Aubameyang made his Bundesliga debut and scored a hat-trick against FC Augsburg, including a goal from his first shot in the league. In the process, Aubameyang also became the first Gabonese player to appear in the Bundesliga. On 27 November, he scored his first Champions League goal in a 3–1 win against Napoli in the group stage of the 2013–14 competition. He later took a penalty against 1860 Munich that propelled Dortmund into the next round of the 2013–14 DFB-Pokal, finishing the year with 13 league goals and 16 goals in all competitions.

On 15 June 2013, Aubameyang scored a hat-trick of penalty kicks in Gabon’s 4–1 2014 FIFA World Cup qualifying win over Niger. He then scored a brace against Burkina Faso in the 2015 Africa Cup of Nations Qualification.

On 13 August 2014, Aubameyang assisted Borussia Dortmund’s first goal and scored the second goal in a 2–0 victory over Bayern Munich in the DFL-Supercup. After scoring the goal, he celebrated by putting on a Spider-Man mask. In Dortmund’s next match, a 4–1 win over Stuttgarter Kickers in the first round of the DFB-Pokal, Aubameyang scored two-second-half goals and provided the assist for Adrián Ramos’ goal. On 13 September, Aubameyang scored his first Bundesliga goal of the season, netting Dortmund’s final goal of their 3–1 win over SC Freiburg. Three days later, Aubameyang scored Dortmund’s second goal in a 2–0 win over future club Arsenal in the first group match of the Champions League.

Aubameyang ended his second season in Dortmund with 25 goals from 46 appearances, including one in the 2015 DFB-Pokal Final, where Dortmund were defeated 3–1 by VfL Wolfsburg at the Olympiastadion.

On 31 July 2015, Aubameyang signed a new contract to last until 2020, saying, “Every part of me wants to be here and I have never wanted to leave.” On 20 August, he scored a brace as Dortmund came from 0–3 down to win 3–4 at Odds BK in the first leg of their Europa League play-off. By scoring in Dortmund’s 1–1 draw with 1899 Hoffenheim on 23 September, Aubameyang became the first player in Bundesliga history to score in each of his team’s opening six matches of a season. He later extended this record to eight matches, scoring in the team’s next two fixtures against Darmstadt 98 and Bayern Munich, before failing to score for the first time in the Bundesliga season in a 2–0 win at Mainz 05.

Aubameyang captained Gabon at the 2015 Africa Cup of Nations, scoring the team’s opening goal of the tournament in their 2–0 win over Burkina Faso on 17 January 2015. He also scored a brace against Mali on 25 March 2015. He is Gabon’s highest goalscorer. He rejected a callup for a pivotal World Cup qualifier at home to the Ivory Coast, which they lost 3–0.

On 30 January 2016, Aubameyang scored his 19th and 20th league goals of the season to give Dortmund a 2–0 home victory over FC Ingolstadt. Aubameyang reached 30 goals in all competitions in a 3–1 victory over VfB Stuttgart in the quarter-final of the 2015–16 DFB-Pokal. In addition to scoring himself, he assisted the side’s other two goals scored by Marco Reus and Henrikh Mkhitaryan. On 10 March 2016, Aubameyang scored for Borussia in their 3–0 win over Tottenham Hotspur in the UEFA Europa League Round of 16 first-leg. A week later, he scored both goals in the 2–1 second-leg victory at White Hart Lane, taking him to 35 goals for the season. In scoring two goals in a 5–1 win against VfL Wolfsburg on 30 April, Aubameyang reached 25 goals in the Bundesliga season, thus ending as the league’s second-top scorer behind Robert Lewandowski of Bayern Munich.

On 4 March 2017, Aubameyang passed 20 Bundesliga goals for the second consecutive season with two goals in a 6–2 defeat of Bayer Leverkusen. Four days later, he scored a hat-trick in a 4–0 win over Benfica to put Dortmund into the quarter-finals of the Champions League. On 20 May, Aubameyang scored twice in Borussia’s final day defeat of Werder Bremen to end the season as the Bundesliga’s top scorer with 31 goals. In the final of the 2016–17 DFB-Pokal on 27 May 2017 he scored the winning goal, a penalty, as Dortmund beat Eintracht Frankfurt 2–1.

On 31 January 2018, Aubameyang signed for Premier League club, Arsenal, for a then-club-record fee, reported to be £56 million.

Aubameyang scored his first goal of the new season in a 3–2 away win over Cardiff City on 2 September 2018. After a flick from Alexandre Lacazette, Aubameyang took a touch before curling the ball past the Cardiff goalkeeper. Aubameyang’s strike from outside the box ended his personal run of 76 consecutive goals from inside the box in club football and was also his 150th goal in league football. Aubameyang made his European debut for Arsenal, in the 4–2 home win over Vorskla Poltava, scoring two goals, before being substituted for Mesut Özil in the 57th minute. Aubameyang’s goals meant that he had been directly involved in 12 goals in 10 appearances for Arsenal at the Emirates Stadium. By October 2018, Aubameyang had tallied 16 goals in Premier League play since joining Arsenal in February. According to Opta statistics, that gave him a minutes per goal ratio of 104.6, which set the record for the best minutes per goal ratio in Premier League history (minimum 10 goals).

Aubameyang scored his first Arsenal hat-trick in the club’s 4–2 win over Valencia on 9 May 2019. Aubameyang also set up the Gunners’ second goal, scored by Alexandre Lacazette. Aubameyang’s hat-trick meant that Arsenal reached the Europa League final, making it the club’s second European final in thirteen years. It also saw him become the first Arsenal player to score a hat-trick in the semi-finals of a European competition.

On 11 August 2019, Aubameyang scored his and Arsenal’s first goal of the season in their 1–0 opening match victory over Newcastle United at St James’ Park, in which he demonstrated perfect technique to cushion a cross from Ainsley Maitland-Niles, to slot the ball past Martin Dúbravka, with José Mourinho hailing the strike as “a moment of genius”. Aubameyang scored his first home goal of the campaign in Arsenal’s next game, a 2–1 win over Burnley on 17 August. Aubameyang scored what turned out to be the winning goal, following an assist from Dani Ceballos. Aubameyang scored his first European goal of the season on 19 September against Eintracht Frankfurt in the Europa League, as Arsenal won 3–0 away from home on matchday 1.

On 5 November 2019, after Granit Xhaka was stripped of the Arsenal captaincy following his angry reaction to getting booed by the Arsenal supporters during their Premier League game against Crystal Palace, head coach Unai Emery confirmed that Aubameyang would take over as the new Arsenal captain.

Aubameyang scored in Arsenal’s 1–1 draw with Crystal Palace on 11 January 2020, but was also sent off for a late challenge on Palace midfielder Max Meyer. Aubameyang was originally given a yellow card for the tackle by referee Paul Tierney, however the card was eventually upgraded to a red card, by the VAR, resulting in Aubameyang’s first-ever red card for the Gunners and would mean that the striker would miss Arsenal’s next three matches against Sheffield United, Chelsea and Arsenal’s FA Cup tie against Bournemouth.

On 29 August 2020, Aubameyang scored a goal in normal time and the fifth and winning penalty in a shoot-out win against Liverpool in the Community Shield, after the game ended 1–1.

On 12 September 2020, Arsenal played their first Premier League game away from home at Craven Cottage against Fulham. Aubameyang scored the third and final goal of the game after a great team effort, he was assisted by Willian. Aubameyang also assisted Alexandre Lacazette’s goal in Arsenal’s 2–1 win over West Ham United on 19 September.

On 15 September 2020, Aubameyang put an end to months of speculation by signing a new three-year contract with Arsenal. Speaking to the Arsenal website, Aubameyang said: “Signing for this special club was never in doubt, it’s thanks to our fans, my team-mates, my family and everybody at this club that I feel like I belong here. I believe in Arsenal. We can achieve big things together. We have something exciting here and I believe the best is to come for Arsenal.” On 1 November 2020, he scored a penalty in a 1–0 away win against Manchester United, to grant his team their first Premier League win at Old Trafford since 2006.