In 1915, a group headed by Pierre, which included outsiders, bought Coleman's stock. Alfred was offended and sued Pierre for breach of trust. The case was settled in Pierre's favor four years later, but his relationship with Alfred suffered greatly, and they did not speak after that.
In 1915, Du Pont was elected a director of General Motors. where he was a significant figure in the success of the company and was noted for building a sizeable personal investment in the company as well as supporting Raskob's proposal for DuPont to invest in the automobile company.
He was a bachelor until age 45. On October 16, 1915, after the death of his mother, he married his first cousin Alice Belin (1872–1944), a daughter of Henry Belin Jr., at 400 Park Avenue, the home of her brother F. Lammot Belin. They were married in New York because Pennsylvania law prohibited cousins from marrying. They had no children.