Pietro Belluschi was born in Ancona, Italy, in 1899. He grew up in Italy and served in the Italian armed forces during World War I when Italy was allied with Great Britain, France, and later the United States. Serving in the army he fought against the Austrians at the battles of Caporetto and Vittorio Veneto. After the war, Belluschi studied at the University of Rome, earning a degree in civil engineering in 1922.

He moved to the United States in 1923, despite speaking no English, and finished his education—as an exchange student on a scholarship—at Cornell University with a second degree in civil engineering. Instead of returning to Italy, he worked briefly as a mining engineer in Idaho earning $5 per day, but he then joined the architectural office of A. E. Doyle in Portland, living in Goose Hollow. He remained in the U.S., as friends in Italy had cautioned him to not return home because of the rise to power of Benito Mussolini and the Fascist government.

At Doyle’s office, Belluschi rose rapidly, soon becoming chief designer. After Doyle died in 1928, the firm took him into partnership in 1933. By 1943, Belluschi had assumed control of the firm by buying out all the other partners and was practicing under his own name.

In 1951, Belluschi became Dean of the architecture and planning school at the Massachusetts Institute of Technology, a position he held until 1965. When he accepted the position of dean and moved to Massachusetts, he transferred his office in Portland to the architecture firm Skidmore, Owings and Merrill. The move reduced his annual income from $150,000 to a salary of $15,000, but was prompted by health concerns attributable to the long hours of managing his office while still designing buildings.

Belluschi was elected a Fellow of the American Academy of Arts and Sciences in 1952. In 1953, he was elected into the National Academy of Design as an Associate member, and became a full member in 1957. He served as a presidential appointee on the U.S. Commission of Fine Arts from 1950 to 1955. He was a Fellow in the American Institute of Architects (AIA), and was awarded the AIA Gold Medal, the highest award given by the institute, in 1972. He was awarded the National Medal of Arts by the National Endowment for the Arts in 1991 for his lifetime achievements. Belluschi was on the jury that selected the winning design for the Vietnam Veterans Memorial in Washington, D.C.

After leaving MIT in 1965, he continued to work. Belluschi would design and consult on both buildings and issues surrounding urban planning. Pietro Belluschi was married first to Helen Hemmila on December 1, 1934, the mother of his two sons, Peter (b. 1939) and Anthony (b. 1941). After her death in 1962, he married in 1965 Marjorie or Margaret (1920-2009). Pietro Belluschi died in Portland on February 14, 1994.