The British Picturegoer magazine, always a supporter of the Lane Sisters, stated that all was not right with Priscilla Lane. In its June 15, 1940 issue, they wondered why "Priscilla was still knocking at the door of major stardom". They felt Warner Bros. was casting her as stooge to such actors as John Garfield and James Cagney. They went on to say Priscilla had great charm and while not a really great dramatic actress, deserved much larger and more important roles than she was getting. The same magazine, two years later on August 22, 1942, referred to their 1940 article and once again expressed disappointment at Warners' treatment of the star. They were unaware that she had already left the studio.
Frank Capra requested her for the lead opposite Cary Grant in Arsenic and Old Lace. The comedy film was completed in early 1942, but was not released until 1944; it was held up by contractual agreement not to distribute the film until the play's long Broadway run was over. It was Priscilla's last Warner film. Her contract was terminated by mutual agreement after five years with the studio.
In early 1942, the engagement to Barry ended after she met Joseph Howard, a young Army Air Corps lieutenant, at a dude ranch in the Mojave Desert. A native of Lawrence, Massachusetts, he had joined the Army Air Corps straight from college in 1939. He was scouting the area for likely sites for air bases and had taken a short vacation. The couple were married on May 22, 1942, in Las Vegas, Nevada, at the home of the executive officer of an Army Air Force gunnery school.