Priyanka starred as the lead actress in the 2010 film Gangor directed by Italo Spinelli. Adapted from Choli Ke Peeche, a short story by the acclaimed Indian writer Mahasweta Devi, Gangor won several awards at the New Jersey Independent South Asian Film Festival, including Best Actress for Bose.

She toured the world for the shows of the play Nirbhaya, written and directed by the South African playwright Yael Farber based on the 2012 Delhi gang rape. The much acclaimed play won the Scotsman Fringe First Award and Herald Angel Award at the Edinburgh Festival Fringe and the Amnesty International Freedom of Expression Award.

In 2013, Priyanka appeared in the advertisement for Tanishq, a jewellery retail brand, as a girl who has a daughter and remarries that drew much attention to her. The ad that was hailed as “path-breaking”, “courageous” and “unique” became a talking point on Twitter and Facebook and had more than three lakh hits on YouTube.

In 2016, Priyanka starred alongside Bhalchandra Kadam and Usha Naik in the Marathi film Half Ticket. A remake of the Tamil film Kaaka Muttai, Half Ticket was awarded the Ecumenical Jury Award at the 57th Zlin International Film Festival 2017 held in the Czech Republic. It was also picked for screening at the Indiwood Panorama Competition section at the 2nd edition of Indiwood Carnival 2016 in Hyderabad.

Bose has completed filming with David Arquette for the upcoming Hollywood movie The MisEducation of Bindu directed by Prarthana Mohan, produced by Edward Timpe, and having Duplass Brothers as executive producers. Recently, she has worked in the 2018 film Mortal directed by André Øvredal and co-starring Nat Wolff. She alternates between Mumbai and Los Angeles to shoot for upcoming Indian and International productions. She appeared in Season 3 of The Good Karma Hospital starring alongside Amanda Redman, Sagar Radia, James Floyd, and Amrita Acharia.