Raima Sen was born on 7 November 1979 in Bombay (present-day Mumbai) to Moon Moon Sen and Bharat Dev Barma and the granddaughter of actress Suchitra Sen who is regarded as the “Mahanayika” of Bengali Cinema. Her sister Riya Sen is also in the Bollywood industry. Their father Bharat Dev Varma is a member of the royal family of Tripura. Her paternal grandmother, Ila Devi, was the princess of Cooch Behar, whose younger sister Gayatri Devi was the Maharani of Jaipur. Her paternal great-grandmother Indira was the only daughter of Maharaja Sayajirao Gaekwad III of Baroda.

Her breakthrough role came when she starred in the Rituparno Ghosh’s film Chokher Bali. After a few more average movies she had a critically acclaimed hit in 2005 with Parineeta, where she played the playmate of the film’s heroine, played by the debutante Vidya Balan. Since then she has had two more hits with the action thriller Dus and the Bengali film Antar Mahal (where she had a very small role). In 2006, she appeared in the film The Bong Connection (co-starring Shayan Munshi). In 2007, she worked in the thriller Manorama Six Feet Under with Abhay Deol. In 2011, she starred in the hit Bengali film Baishe Srabon, opposite Parambrata Chatterjee.

2014 saw Sen as the leading lady in the critically acclaimed Hrid Majharey, the first Bengali movie based on the works of William Shakespeare, and presented as a tribute on the 450th year of birth of the Bard. She co-stars with Abir Chatterjee and Indrasish Roy in this dark love-story by debutant filmmaker Ranjan Ghosh. The film has earned a rare recommendation from the very prestigious Film London in its list of world cinema based on the plays of Shakespeare. The film and its screenplay have also been included in the prestigious UGC Literature Archive. It is also famous for being the only other Bengali film after Sabuj Dweeper Raja (1979) to be shot in the Andaman and Nicobar Islands.

In 2016, she was seen in Bollywood Diaries, a film written and directed by K.D. Satyam. The film also stars Ashish Vidyarthi and Salim Diwan. Amazon Prime The Last Hour Web Series will release in 2020 Ending in this series Raima Sen and sanjay kapoor playing the main role this series directed by Amit Kumar.