At the same time, Telgemeier was invited to join Girlamatic, a subscription-based webcomics site with an emphasis on stories for young women. The disciplined structure and schedule of publishing a weekly webcomic encouraged Telgemeier to develop the autobiographical story that would later be published in 2010 as Smile. By the time she had completed work on the Babysitters Club adaptations in 2008, she had developed a substantial amount of Smile and received encouragement from Scholastic to continue work.
In February 2010, Telgemeier released Smile, which reached The New York Times bestseller list in 2011 and remained on the list for over 220 weeks.