In 1979 Rambo Amadeus started off in a band called “Radioaktivni otpad,” which was short lived. He was also in a band called “The Blues Band.” He didn’t like the content produced, so he rearranged the setup. The band lasted his four high school years. The band played in Herceg Novi, Nikšić and Igalo (5 km distance from Herceg Novi).

Before pursuing music and performing arts as a career choice, Pušić was an accomplished competitive sailor. Between 1972 and 1984, he represented Yugoslavia in numerous international regattas. During this period he was champion of Montenegro several times, an 8-time South-Adriatic champion, national title winner in the junior category, as well as International Đerdap Cup winner in 1980. He still occasionally attends and participates in some recreational sailing regattas in the Gulf of Kotor.

In 1985, he moved to Belgrade in pursuit of higher education. Parallel to his university studies, he also played with various amateur bands and musicians.

In 1988, he dropped into the music scene out of nowhere with his debut album O tugo jesenja. His sound was a seemingly coarse blend of folkish ululations and opera, further mixed in with humorous lyrics and classic guitar riffs. Since very few people had prior knowledge of him, Rambo was delighted in creating confusion by introducing himself as Nagib Fazlić Nagon, a mine shaft operator who saved up enough money to record an album. He also jokingly referred to his own musical style as turbo folk, long before term would begin to be referred as actually musical style which critics refer to be grave social connotation and become to symbolise the moral and cultural decline throughout the Balkans during the wars of the 1990s.

His next album Hoćemo gusle was released in 1989 and gave a small taste of Rambo’s future musical direction – overt political satire. The track “Amerika i Engleska (biće zemlja proleterska)” was originally supposed to be named “Kataklizma komunizma” (Cataclysm of Communism) but local authorities did not allow it. The album title pokes fun at a bizarre event from the 1989 protests in Montenegro that eventually grew into the anti-bureaucratic revolution that swept Milo Đukanović, Momir Bulatović, and Svetozar Marović into power. Protesters were heard chanting “Hoćemo Ruse” (“We want the Russians”), but when the authorities and state-controlled media criticized them for it, many quickly began backpedaling by claiming they actually chanted “Hoćemo gusle” (“We want gusle”).

During “Belgrade spring” festival in 1992. he showed civil courage when he interrupted a concert by “Bebi Dol” during live TV broadcast and said to tens of thousands of viewers:

After live album KPGS (taped on December 29, 1992 in Skopje) that included new studio track “Karamba karambita” followed by a greatest hits compilation Izabrana dela 1989–1994, Rambo recorded peculiar new material during July 1995 in Paris with Goran Vejvoda. Released the following year as Mikroorganizmi, it featured inaccessible, moody sound garnered with terse, experimental music marking a sizable departure from his usual antics.

Extensive tour followed and it again included Slovenia (live album was recorded over two Ljubljana concerts in April 1997 and later released as Koncert u KUD France Prešeren), as well as Bosnia where Rambo appeared as a guest at Sejo Sexon’s Zabranjeno pušenje gig in Sarajevo. That appearance in December 1997 was the first post-war visit by a Montenegrin performer to the Bosnia.

On June 9, 1998, Rambo played Belgrade’s Dom Sindikata hall in what he announced to be the farewell performance before retirement. Even if many doubted his sincerity, the concert was a memorable one. Soon, Rambo packed his bags and left for the Netherlands, though not before squeezing in two more shows in Bosnia. In the Netherlands, he worked a series of menial jobs including construction, before deciding to return to Belgrade after only 4 months abroad. Back home, not surprisingly, he also returned to music and continued to break down inter-ethnic barriers: on December 10, 1998, he and Margita Stefanović played a show in Pula at the local cinema with KUD Idijoti, which was a first opportunity since the war for a Croatian audience to see performers from Serbia and Montenegro.

In 2003, he voiced Rafiki in the Serbian-language dub of The Lion King.

In 2004, Rambo released his third live album Bolje jedno vruće pivo nego četri ladna, which was followed by the studio album Oprem dobro in mid-2005.

He made a song “Dikh tu kava” in collaboration with ethno-jazz fusion band Kal, and in 2007 he appeared on their album as a featured artist in the song “Komedija” (“Comedy”).

In autumn 2007 he performed a performance called “Mixing of alternative rocks”, when he “played” on 12 concrete mixers in front of the audience, during The Alternative Rock Festival in SKC, Belgrade.

For the purpose of the New Year’s show on RTV, he appeared in the song “Rakija” followed by Zorule, the traditional folk orchestra. This song was used later as one of the tracks for “Vratiće se rode” TV serial. In February 2008, Rambo Amadeus performed as a guest star of The RTS Big Band jazz orchestra, for their 60th Anniversary.

Hipishizik Metafizik is his latest studio album, released for PGP RTS in July 2008.

In 2013 he released a video for the new single O’Ruk on the Road Again with Three Winnettous.

In 2015 he released the album “Vrh Dna”, which featured previously unreleased track “Rano Za Početak” from 2011, and he retitled it “Samo Balade” for the album’s release.

In 2016, he landed two voice-work roles, as Mighty Eagle in the Croatian-language and Serbian-language version of The Angry Birds Movie, and as Crush in the Serbian-language version Finding Dory.

In 2018 he has tried to represent Serbia in Eurovision Song Contest 2018 with the song Nema Te, a duet with jazz singer Beti Đorđević. They performed the song in Beovizija 2018. and came 9th.