He also played in the 2006 film The Sasquatch Dumpling Gang (also known as The Sasquatch Gang), alongside Justin Long, and in American Son along Nick Cannon. He also appeared in the 2011 film In Time. Santiago appeared in episodes of the television series My Name is Earl, Crossing Jordan, Law & Order: LA and Dexter. In the Ash vs. Evil Dead television series from 2015-2018, he portrayed Pablo Simon Bolivar, an immigrant co-worker who becomes Ash's sidekick.