The band would go on to release Lo Que Andábamos Buscando, their second album in 2001 which spawned their greatest hit, “El Abandonao” which was sung by Reyli. During this time, the band would represent Mexico in the famous Chilean festival Viña del Mar International Song Festival.

In 2003, Reyli announced that he had plans to release a solo album, and that he was to stay in Elefante. After the announcement, however, he left the band. No announcement was ever given to the Mexican media.

After leaving the band, Reyli started composing for what he planned to be his solo debut, a romantic pop very different from the Rock Latino he sang in Elefante. En la Luna was released on September 28, 2004.

In October 2005, Reyli released “Amor del Bueno”, which was to be the defining third single. The song was welcomed warmly by radio stations, which put the song on high rotation. The song charted as high as 11 in the U.S. Hot Latin Tracks.

On February 26, 2006, En la Luna, Special Edition was released. Almost a year and half after the original release of En la Luna, Reyli included the full studio version of “No Era Necesario”, since the original album only featured a demo version. Also, a reggaetón version of “Al Fin Me Armé de Valor” was included as the final track. In addition to the 2 extra tracks, there was an accompanying DVD with video clips and footage from live performance.

Released digitally on May 12, 2009, Que Vueltas da la vida was available to the general public on June 9, 2009. Of his third studio effort, the singer-songwriter said, “This album will make history in my career and in my life.” He went on to say that the album, “carries my happiness, my longings, it reflects my status today, my way of being now, my sentimental state, my stage in life.” The album was produced and directed by Andrés Castro, who has worked with the likes of Carlos Vives and Juanes. “This marvelous album, Que vueltas da la vida, we wrote it, assembled it, gave it strength, Andrés and I; Andrés is Colombian, a producer, a guitarist, my adored brother. We started in September, in one afternoon we wrote six songs and from there he started to put everything together, the answers were very clear that the unedited album had to be assembled and eleven days later, we had the repertory pulled together.”

On September 12, 2009, Mario Domm (of Camila) presented Reyli with the Gold Disc, for having sold more than 50,000 copies of Que Vueltas da la vida.

In 2012, Reyli Barba was revealed as being the father of Ana Bárbara’s third son, Jeronimo.