In 2009, after four years of work, Crumb produced The Book of Genesis, an unabridged illustrated graphic novel version of the biblical Book of Genesis. In 2016, the Seattle Museum of Art displayed the original drawings for the Book of Genesis as part of an exhibit entitled "Graphic Masters: Dürer, Rembrandt, Hogarth, Goya, Picasso, R. Crumb."
In 2009, Crumb drew the artwork for a 10-CD anthology of French traditional music compiled by Guillaume Veillet for Frémeaux & Associés. The following year, he created three artworks for Christopher King's Aimer Et Perdre: To Love And To Lose: Songs, 1917–1934 and, in 2011, he once again played mandolin on an Eden and John's East River String Band album (Be Kind to a Man When He's Down) for which he also created the album cover artwork.