Pattinson executive-produced and starred in the film Remember Me, which was released on 12 March 2010. Though the film received mixed reviews, some critics praised his performance. Jake Coyle of The Associated Press said that "The young actor has an unmistakable screen presence. However in Remember Me, he pours it on thickly and self-consciously. With low eyes, sleeves rolled up just so and cigarette drooping artfully from his mouth, Tyler (like Edward Cullen) is a reluctant romantic." Ian Nathan of Empire Online stated that "this is the best thing he's done." and Kirk Honeycutt of The Hollywood Reporter praised his chemistry with co-star Emilie de Ravin in the film, stating that the "scenes between Pattinson and de Ravin exude genuine charm."
In November 2010, Pattinson was approached by Burberry to be the face of their brand with a £1m deal, which he turned down.
Pattinson plays the guitar and piano since age four, and writes his own music. He appears as the singer of two songs on the Twilight soundtrack: "Never Think", which he co-wrote with Sam Bradley, and "Let Me Sign", which was written by Marcus Foster and Bobby Long. The songs were included in the film after director Catherine Hardwicke added Pattinson's recordings into an early cut without his knowledge, and he agreed that "one of them specifically, it really made the scene better. It was like it was supposed to be there." The soundtrack for the film How to Be features three original songs performed by Pattinson and written by composer Joe Hastings. Pattinson has said, "I've never really recorded anything – I just played in pubs and stuff", and when asked about a professional music career, he said, "Music is my back-up plan if acting fails." In 2010, Pattinson was awarded the "Hollywood's Most Influential Top Unexpected Musicians" award.
Pattinson supports and promotes the ECPAT UK's campaign Stop Sex Trafficking of Children and Young People to stop human trafficking. At 2009 Cannes Film Festival amfAR event, he raised $56,000 for the cause. In June 2010, he donated his own artwork to PACT which auctioned on eBay, to help the organisation working for missing children. He also donated a sketch, drawn by himself, called Unfinished City which auctioned at $6,400. The money from the auction went to an Arizona-based homeless center Ozanam Manor. In January 2010, he participated in charity telethon Hope for Haiti Now: A Global Benefit for Earthquake Relief. In March 2010, he signed off guitar, the money raised from the auction went to Midnight Mission. He raised $80,000 for the GO Campaign by donating a meet and greet with himself on the set of Breaking Dawn and later again by auctioning a private screening of The Twilight Saga: Breaking Dawn – Part 1.
Britain's The Sunday Times "Rich List" put him on its "list of young millionaires" in the UK, worth £13 million. In 2010, Pattinson was named by Time magazine as one of the 100 most influential people in the world, and he was featured in the Forbes Celebrity 100 list. On 14 November 2010, Pattinson received two BBC Radio 1 Teen Awards, Best Dressed and Best Actor.
A wax statue of Pattinson was added to the Madame Tussauds collection in London and New York City in 2010. Pattinson along with his Twilight co-stars, Kristen Stewart and Taylor Lautner put his signature, hand and foot prints in wet concrete at Grauman's Chinese Theatre on 3 November 2011. On 19 February 2014, Russian astronomer Timur Kryachko named an asteroid he had discovered after Pattinson, as 246789 Pattinson.