In 1965 Fertel, realizing she needed to earn more money to send her sons to college, found a classified ad in the Times-Picayune offering a restaurant for sale, the original Chris' Steak House, a 60-seat restaurant at 1100 North Broad St, New Orleans. When she realized that it had opened on February 5, 1927, the day she was born, she took this as an omen. Ignoring the advice of her banker, lawyer, and friends, she mortgaged her house to purchase the restaurant, even though the business had previously failed six times under the previous owner, Chris Matulich, and despite knowing nothing about the restaurant business. She initially planned to raise just $18,000 to cover the purchase price, until it was pointed out to her that she would need an additional $4,000 to cover the cost of renovations and food. On her first day, May 24, 1965, she sold 35 steaks at $5 each. Within six months, she had made over double her annual salary from her previous job.
During her lifetime, she was known for her charitable work. In 1965, when Hurricane Betsy hit New Orleans, she was left without power, and realized that the food in her restaurant was in danger of spoiling. She cooked everything and provided free steak meals to disaster workers and victims in the local area. She paid for the education of numerous children, provided counseling for women starting businesses, and contributed to local schools.